Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration
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The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesionErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration.Neurotrophin-regulated signalling pathwaysTrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphologyTiam1 as a signaling mediator of nerve growth factor-dependent neurite outgrowthNMDA receptor couples Rac1-GEF Tiam1 to direct oligodendrocyte precursor cell migrationBeta1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelinationPhosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms.Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neuronsSmall G protein signaling in neuronal plasticity and memory formation: the specific role of ras family proteinsVimentin regulates lung cancer cell adhesion through a VAV2-Rac1 pathway to control focal adhesion kinase activity.RNAi mediated Tiam1 gene knockdown inhibits invasion of retinoblastomaIdentification of a negative regulatory region for the exchange activity and characterization of T332I mutant of Rho guanine nucleotide exchange factor 10 (ARHGEF10).Lipotoxicity augments glucotoxicity-induced mitochondrial damage in the development of diabetic retinopathyEvidence for the importance of OxPAPC interaction with cysteines in regulating endothelial cell functionEssential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development.Big roles for small GTPases in the control of directed cell movement.Myelination: all about Rac 'n' roll.Remyelination of the central nervous system: a valuable contribution from the periphery.Mechanical stretch decreases migration of alveolar epithelial cells through mechanisms involving Rac1 and Tiam1.The function of RhoGTPases in axon ensheathment and myelination.Simvastatin induces a central hypotensive effect via Ras-mediated signalling to cause eNOS up-regulation.The rho-specific guanine nucleotide exchange factor Dbs regulates breast cancer cell migration.EphA2 signaling following endocytosis: role of Tiam1.Lysophosphatidic acid (LPA) and its receptor, LPA1 , influence embryonic schwann cell migration, myelination, and cell-to-axon segregation.Rab35, acting through ACAP2 switching off Arf6, negatively regulates oligodendrocyte differentiation and myelination.Molecular signaling mechanisms of axon-glia communication in the peripheral nervous system.Rac1 controls Schwann cell myelination through cAMP and NF2/merlin.Neurotrophin Signaling and Stem Cells-Implications for Neurodegenerative Diseases and Stem Cell Therapy.Regulating Rac in the nervous system: molecular function and disease implication of Rac GEFs and GAPs.Transient neonatal diabetes mellitus gene Zac1 impairs insulin secretion in mice through Rasgrf1KIR2DL5 mutation and loss underlies sporadic dermal neurofibroma pathogenesis and growth.Dock8 interacts with Nck1 in mediating Schwann cell precursor migrationHOXC8-Dependent Cadherin 11 Expression Facilitates Breast Cancer Cell Migration through Trio and Rac.Myopathy caused by HRAS germline mutations: implications for disturbed myogenic differentiation in the presence of constitutive HRas activation.The Tiam1 guanine nucleotide exchange factor is auto-inhibited by its pleckstrin homology coiled-coil extension domain.Homer, Spikar, and Other Drebrin-Binding Proteins in the Brain.Mechanistic regulation of epithelial-to-mesenchymal transition through RAS signaling pathway and therapeutic implications in human cancer.Mutations in dock1 disrupt early Schwann cell development
P2860
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P2860
Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration
description
2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2005
@ast
im Oktober 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/10/11)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/10/11)
@nl
наукова стаття, опублікована в жовтні 2005
@uk
name
Ras activation of a Rac1 excha ...... induced Schwann cell migration
@ast
Ras activation of a Rac1 excha ...... induced Schwann cell migration
@en
Ras activation of a Rac1 excha ...... induced Schwann cell migration
@nl
type
label
Ras activation of a Rac1 excha ...... induced Schwann cell migration
@ast
Ras activation of a Rac1 excha ...... induced Schwann cell migration
@en
Ras activation of a Rac1 excha ...... induced Schwann cell migration
@nl
prefLabel
Ras activation of a Rac1 excha ...... induced Schwann cell migration
@ast
Ras activation of a Rac1 excha ...... induced Schwann cell migration
@en
Ras activation of a Rac1 excha ...... induced Schwann cell migration
@nl
P2093
P2860
P921
P356
P1476
Ras activation of a Rac1 excha ...... induced Schwann cell migration
@en
P2093
Akito Tanoue
Eric M. Shooter
Jonah R. Chan
Junji Yamauchi
Yuki Miyamoto
P2860
P304
14889–14894
P356
10.1073/PNAS.0507125102
P407
P577
2005-10-11T00:00:00Z