GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
about
Hsp70-Hsp40 chaperone complex functions in controlling polarized growth by repressing Hsf1-driven heat stress-associated transcriptionDLC-1: a Rho GTPase-activating protein and tumour suppressorThe WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIαType I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activationFunctional SNP of ARHGEF10 confers risk of atherothrombotic strokeRac1-induced cell migration requires membrane recruitment of the nuclear oncogene SETThe nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damageDLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanismsHGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathwayThe atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamicsEphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formationTargeting and activation of Rac1 are mediated by the exchange factor beta-Pix.The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesionActivity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex.Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.WGEF activates Rho in the Wnt-PCP pathway and controls convergent extension in Xenopus gastrulationThe HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding moduleCrucial structural role for the PH and C1 domains of the Vav1 exchange factorAsef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation elementThe human minor histocompatibility antigen 1 is a RhoGAPAn autosomal dominant cerebellar ataxia linked to chromosome 16q22.1 is associated with a single-nucleotide substitution in the 5' untranslated region of the gene encoding a protein with spectrin repeat and Rho guanine-nucleotide exchange-factor domModulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT.Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafnessRational design of small molecule inhibitors targeting RhoA subfamily Rho GTPasesPLEKHG2 promotes heterotrimeric G protein βγ-stimulated lymphocyte migration via Rac and Cdc42 activation and actin polymerization.ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion.GEF what? Dock180 and related proteins help Rac to polarize cells in new waysParacingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctionsDesign of versatile biochemical switches that respond to amplitude, duration, and spatial cuesErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration.Investigating the function of Rho family GTPases during Salmonella/host cell interactionsNet1 and Myeov: computationally identified mediators of gastric cancerFGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane rufflesKalirin-7 is required for synaptic structure and functionThe F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesisEndogenous RhoG is dispensable for integrin-mediated cell spreading but contributes to Rac-independent migration.Function of the N-terminus of zizimin1: autoinhibition and membrane targeting.Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domainFARP1 promotes the dendritic growth of spinal motor neuron subtypes through transmembrane Semaphorin6A and PlexinA4 signaling
P2860
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P2860
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
description
2005 nî lūn-bûn
@nan
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
@ast
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
@en
type
label
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
@ast
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
@en
prefLabel
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
@ast
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
@en
P2093
P3181
P356
P1476
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
@en
P2093
P2888
P304
P3181
P356
10.1038/NRM1587
P407
P577
2005-02-01T00:00:00Z
P5875
P6179
1006050511