Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4
about
The dynamic cilium in human diseasesHuman and mouse mutations in WDR35 cause short-rib polydactyly syndromes due to abnormal ciliogenesisTULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary ciliaSubunit interactions and organization of the Chlamydomonas reinhardtii intraflagellar transport complex A proteinsCilia/Ift protein and motor -related bone diseases and mouse modelsEndothelial cilia are essential for developmental vascular integrity in zebrafishArchitecture and function of IFT complex proteins in ciliogenesisTrafficking in and to the primary cilium.Cranioectodermal Dysplasia, Sensenbrenner syndrome, is a ciliopathy caused by mutations in the IFT122 geneIntraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway componentsThe IFT-A complex regulates Shh signaling through cilia structure and membrane protein traffickingATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis.IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transportComplex interactions between genes controlling trafficking in primary ciliaMutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathiesArl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteinsDisruption of IFT complex A causes cystic kidneys without mitotic spindle misorientationMouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signalingThe primary cilium: a signalling centre during vertebrate developmentIntraflagellar transport protein IFT20 is essential for male fertility and spermiogenesis in miceThe eukaryotic flagellum makes the day: novel and unforeseen roles uncovered after post-genomics and proteomics data.Dual Phosphorylation of suppressor of fused (Sufu) by PKA and GSK3beta regulates its stability and localization in the primary cilium.The emerging face of primary cilia.Functional consequences of copy number variants in miscarriage.Clinical implications of hedgehog signaling pathway inhibitorsThe ciliopathy gene Rpgrip1l is essential for hair follicle development.Deletion of IFT80 Impairs Epiphyseal and Articular Cartilage Formation Due to Disruption of Chondrocyte Differentiation.Components of Intraflagellar Transport Complex A Function Independently of the Cilium to Regulate Canonical Wnt Signaling in Drosophila.Structural and Functional Recovery of Sensory Cilia in C. elegans IFT Mutants upon Aging.The role of retrograde intraflagellar transport in flagellar assembly, maintenance, and function.A tissue-specific role for intraflagellar transport genes during craniofacial development.A novel ICK mutation causes ciliary disruption and lethal endocrine-cerebro-osteodysplasia syndromeThe relationship between sonic Hedgehog signaling, cilia, and neural tube defectsDampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia.Transcriptional profiling of C. elegans DAF-19 uncovers a ciliary base-associated protein and a CDK/CCRK/LF2p-related kinase required for intraflagellar transport.Activation of the hedgehog-signaling pathway in human cancer and the clinical implications.The primary cilium as a Hedgehog signal transduction machine.Cilia in cell signaling and human disorders.Hedgehog signaling in skin cancersPrimary cilia and organogenesis: is Hedgehog the only sculptor?
P2860
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P2860
Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4
description
2009 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
im Januar 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/01/01)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/01/01)
@nl
наукова стаття, опублікована в січні 2009
@uk
مقالة علمية (نشرت عام 2009)
@ar
name
Defective ciliogenesis, embryo ...... the DNA repair gene Med1/Mbd4
@ast
Defective ciliogenesis, embryo ...... the DNA repair gene Med1/Mbd4
@en
Defective ciliogenesis, embryo ...... the DNA repair gene Med1/Mbd4
@nl
type
label
Defective ciliogenesis, embryo ...... the DNA repair gene Med1/Mbd4
@ast
Defective ciliogenesis, embryo ...... the DNA repair gene Med1/Mbd4
@en
Defective ciliogenesis, embryo ...... the DNA repair gene Med1/Mbd4
@nl
prefLabel
Defective ciliogenesis, embryo ...... the DNA repair gene Med1/Mbd4
@ast
Defective ciliogenesis, embryo ...... the DNA repair gene Med1/Mbd4
@en
Defective ciliogenesis, embryo ...... the DNA repair gene Med1/Mbd4
@nl
P2093
P2860
P3181
P1476
Defective ciliogenesis, embryo ...... the DNA repair gene Med1/Mbd4
@en
P2093
Alfonso Bellacosa
Amelie Calmont
Baolin Wang
Chengbing Wang
Delphine Champeval
Elena Caretti
John Burch
Kenneth S. Zaret
Lionel Larue
Maria Rosaria Bassi
P2860
P304
P3181
P356
10.1016/J.YDBIO.2008.10.020
P407
P577
2009-01-01T00:00:00Z