The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity
about
Variant base excision repair proteins: contributors to genomic instabilityThymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repairThe thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16(INK4a) and hMLH1 genesDNA mismatch repair: molecular mechanism, cancer, and ageingGut Microbiota Imbalance and Base Excision Repair Dynamics in Colon CancerDNA glycosylases: in DNA repair and beyondCilia/Ift protein and motor -related bone diseases and mouse modelsBase excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracilMBD4 interacts with and recruits USP7 to heterochromatic fociInvolvement of MBD4 inactivation in mismatch repair-deficient tumorigenesisMBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological rolesEpigenetic downregulation of the DNA repair gene MED1/MBD4 in colorectal and ovarian cancerDefective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR.Histone/protein deacetylase SIRT1 is an anticancer therapeutic target.Hydroxymethylated cytosines are associated with elevated C to G transversion rates.DNA methyltransferases, DNA damage repair, and cancerSMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stressMED1: a central molecule for maintenance of genome integrity and response to DNA damageTranscriptome analysis of a rotenone model of parkinsonism reveals complex I-tied and -untied toxicity mechanisms common to neurodegenerative diseases.Complex relationship between mismatch repair proteins and MBD4 during immunoglobulin class switch recombinationCommentary: DNA base excision repair defects in human pathologies.The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylaseGenomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous RecombinationBase excision repair in physiology and pathology of the central nervous system5-Fluorouracil mediated anti-cancer activity in colon cancer cells is through the induction of Adenomatous Polyposis Coli: Implication of the long-patch base excision repair pathway.Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene.The mismatch repair-mediated cell cycle checkpoint response to fluorodeoxyuridine.Participation of DNA repair in the response to 5-fluorouracil.Uracil in DNA: consequences for carcinogenesis and chemotherapyInteraction with the DNA Repair Protein Thymine DNA Glycosylase Regulates Histone Acetylation by p300.Inhibition of uracil DNA glycosylase sensitizes cancer cells to 5-fluorodeoxyuridine through replication fork collapse-induced DNA damage.The Roles of the Methyl-CpG Binding Proteins in Cancer.DNA damage and repair in human cancer: molecular mechanisms and contribution to therapy-related leukemias.TAS-102, a novel antitumor agent: a review of the mechanism of action.MBD4 Facilitates Immunoglobulin Class Switch Recombination.Tagging polymorphisms of methyl-CpG binding domain 4 and gastric cardiac adenocarcinoma risk in a Chinese population.MLH1 deficiency enhances tumor cell sensitivity to ganciclovir.A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells.The Mbd4 DNA glycosylase protects mice from inflammation-driven colon cancer and tissue injury.
P2860
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P2860
The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity
description
2003 nî lūn-bûn
@nan
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The base excision repair enzym ...... smatch repair system integrity
@ast
The base excision repair enzym ...... smatch repair system integrity
@en
The base excision repair enzym ...... smatch repair system integrity
@nl
type
label
The base excision repair enzym ...... smatch repair system integrity
@ast
The base excision repair enzym ...... smatch repair system integrity
@en
The base excision repair enzym ...... smatch repair system integrity
@nl
prefLabel
The base excision repair enzym ...... smatch repair system integrity
@ast
The base excision repair enzym ...... smatch repair system integrity
@en
The base excision repair enzym ...... smatch repair system integrity
@nl
P2093
P2860
P50
P921
P3181
P356
P1476
The base excision repair enzym ...... smatch repair system integrity
@en
P2093
Alfonso Bellacosa
Anna Marie Skalka
Christophe Alberti
David Turner
Domenico Albino
Lionel Larue
Neal J Meropol
Valeria Masciullo
P2860
P304
15071-15076
P3181
P356
10.1073/PNAS.2334585100
P407
P577
2003-11-12T00:00:00Z