Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1
about
Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene programH3K9me2/3 binding of the MBT domain protein LIN-61 is essential for Caenorhabditis elegans vulva developmentHemp, an mbt domain-containing protein, plays essential roles in hematopoietic stem cell function and skeletal formationLoss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemiaMouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesisThe polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early developmentChromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice.Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3.LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes.Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion.Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain.Differential contributions of haematopoietic stem cells to foetal and adult haematopoiesis: insights from functional analysis of transcriptional regulators.Novel multiple sclerosis susceptibility loci implicated in epigenetic regulationMBT domain proteins in development and diseaseRBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.Recurrent translocation (10;17)(p15;q21) in acute poorly differentiated myeloid leukemia likely results in ZMYND11-MBTD1 fusion.Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase.
P2860
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P2860
Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1
description
2005 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մայիսին հրատարակված գիտական հոդված
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artículu científicu espublizáu en 2005
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im Mai 2005 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2005/05/18)
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vědecký článek publikovaný v roce 2005
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wetenschappelijk artikel (gepubliceerd op 2005/05/18)
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наукова стаття, опублікована в травні 2005
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مقالة علمية (نشرت في 18-5-2005)
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name
Impaired maturation of myeloid ...... l Polycomb group protein MBT-1
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Impaired maturation of myeloid ...... l Polycomb group protein MBT-1
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Impaired maturation of myeloid ...... l Polycomb group protein MBT-1
@nl
type
label
Impaired maturation of myeloid ...... l Polycomb group protein MBT-1
@ast
Impaired maturation of myeloid ...... l Polycomb group protein MBT-1
@en
Impaired maturation of myeloid ...... l Polycomb group protein MBT-1
@nl
prefLabel
Impaired maturation of myeloid ...... l Polycomb group protein MBT-1
@ast
Impaired maturation of myeloid ...... l Polycomb group protein MBT-1
@en
Impaired maturation of myeloid ...... l Polycomb group protein MBT-1
@nl
P2860
P921
P3181
P356
P1433
P1476
Impaired maturation of myeloid ...... l Polycomb group protein MBT-1
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P2093
Satoko Arai
Toru Miyazaki
P2860
P304
P3181
P356
10.1038/SJ.EMBOJ.7600654
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P577
2005-05-18T00:00:00Z