The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis
about
Mammary Development and Breast Cancer: A Wnt PerspectiveCrosstalk of the Insulin-Like Growth Factor Receptor with the Wnt Signaling Pathway in Breast CancerPositional variations in mammary gland development and cancerFrizzled homolog proteins, microRNAs and Wnt signaling in cancerLRP5 and LRP6 in development and diseaseSmall molecule antagonists of the Wnt/β-catenin signaling pathway target breast tumor-initiating cells in a Her2/Neu mouse model of breast cancerThe Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineageThe Wnt co-receptor Lrp6 is required for normal mouse mammary gland developmentWnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culturePygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylationMutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearanceA novel mouse model for non-invasive single marker tracking of mammary stem cells in vivo reveals stem cell dynamics throughout pregnancyEvidence for a stem cell hierarchy in the adult human breastThe internally truncated LRP5 receptor presents a therapeutic target in breast cancerMMTV-Wnt1 and -DeltaN89beta-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumorsWnt4 is not sufficient to induce lobuloalveolar mammary development.Pea3 transcription factors and wnt1-induced mouse mammary neoplasiaWnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis.Wnt1 expression induces short-range and long-range cell recruitments that modify mammary tumor development and are not induced by a cell-autonomous beta-catenin effectorLRP6 overexpression defines a class of breast cancer subtype and is a target for therapy.The Terminal End Bud: the Little Engine that Could.Molecular mechanisms guiding embryonic mammary gland development.Wnt signaling can substitute for estrogen to induce division of ERalpha-positive cells in a mouse mammary tumor model.High-resolution association mapping of number of teats in pigs reveals regions controlling vertebral development.Differentiation generates paracrine cell pairs that maintain basaloid mouse mammary tumors: proof of concept.Epithelial stem cells: an epigenetic and Wnt-centric perspective.LRP5 polymorphism-A potential predictor of the clinical outcome in advanced gastric cancer patients treated with EOF regimen.SOST and DKK: Antagonists of LRP Family Signaling as Targets for Treating Bone Disease.Bovine mammary stem cells: cell biology meets production agriculture.Wnt and mammary stem cells: hormones cannot fly wingless.Genotoxic exposure during juvenile growth of mammary gland depletes stem cell activity and inhibits Wnt signaling.Key signaling nodes in mammary gland development and cancer: β-catenin.Wnt signaling and the control of human stem cell fate.Krt6a-positive mammary epithelial progenitors are not at increased vulnerability to tumorigenesis initiated by ErbB2.Efficacy of mesenchymal stem cells in suppression of hepatocarcinorigenesis in rats: possible role of Wnt signaling.Ror2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium.Mammary cells with active Wnt signaling resist ErbB2-induced tumorigenesisSLIT/ROBO1 signaling suppresses mammary branching morphogenesis by limiting basal cell numberMesd is a general inhibitor of different Wnt ligands in Wnt/LRP signaling and inhibits PC-3 tumor growth in vivo.LRP5 deficiency down-regulates Wnt signalling and promotes aortic lipid infiltration in hypercholesterolaemic mice.
P2860
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P2860
The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis
description
2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2006
@ast
im November 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/11/17)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/11/17)
@nl
наукова стаття, опублікована в листопаді 2006
@uk
name
The Wnt signaling receptor Lrp ...... and Wnt1-induced tumorigenesis
@ast
The Wnt signaling receptor Lrp ...... and Wnt1-induced tumorigenesis
@en
The Wnt signaling receptor Lrp ...... and Wnt1-induced tumorigenesis
@nl
type
label
The Wnt signaling receptor Lrp ...... and Wnt1-induced tumorigenesis
@ast
The Wnt signaling receptor Lrp ...... and Wnt1-induced tumorigenesis
@en
The Wnt signaling receptor Lrp ...... and Wnt1-induced tumorigenesis
@nl
prefLabel
The Wnt signaling receptor Lrp ...... and Wnt1-induced tumorigenesis
@ast
The Wnt signaling receptor Lrp ...... and Wnt1-induced tumorigenesis
@en
The Wnt signaling receptor Lrp ...... and Wnt1-induced tumorigenesis
@nl
P2093
P2860
P3181
P356
P1476
The Wnt signaling receptor Lrp ...... and Wnt1-induced tumorigenesis
@en
P2093
Caroline M Alexander
Cassandra R Zylstra
Charlotta Lindvall
Nicole C Evans
P2860
P304
35081-35087
P3181
P356
10.1074/JBC.M607571200
P407
P577
2006-09-13T00:00:00Z