Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina
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Consequences of lineage-specific gene loss on functional evolution of surviving paralogs: ALDH1A and retinoic acid signaling in vertebrate genomesRetinoic acid synthesis and functions in early embryonic developmentIdentification of SOX3 as an XX male sex reversal gene in mice and humansRetinoic acid synthesis and signaling during early organogenesisMultiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out miceRetinoic acid regulation of the somitogenesis clockNon-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamilySignaling through retinoic acid receptors in cardiac development: Doing the right things at the right timesMechanisms of retinoic acid signalling and its roles in organ and limb developmentHomozygous Deletion of Glutathione Peroxidase 1 and Aldehyde Dehydrogenase 1a1 Genes Is Not Associated with Schizophrenia-Like Behavior in MiceDynamic expression of retinoic acid-synthesizing and -metabolizing enzymes in the developing mouse inner ear.Retinoic acid synthesis controlled by Raldh2 is required early for limb bud initiation and then later as a proximodistal signal during apical ectodermal ridge formationRDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ developmentGenetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acidOpposing actions of cellular retinol-binding protein and alcohol dehydrogenase control the balance between retinol storage and degradationRetinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterningAldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systemsThe retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic developmentA newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatmentAldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulationRetinoic acid promotes the generation of pancreatic endocrine progenitor cells and their further differentiation into beta-cellsRetinoic acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2Retinoic acid functions as a key GABAergic differentiation signal in the basal ganglia.Aldehyde dehydrogenase 1-positive nigrostriatal dopaminergic fibers exhibit distinct projection pattern and dopamine release dynamics at mouse dorsal striatum.Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma.RDH10 oxidation of Vitamin A is a critical control step in synthesis of retinoic acid during mouse embryogenesis.Sex specific retinoic acid signaling is required for the initiation of urogenital sinus bud development.The hepatic Raldh1 expression is elevated in Zucker fatty rats and its over-expression introduced the retinal-induced Srebp-1c expression in INS-1 cells.Corneal aldehyde dehydrogenases: multiple functions and novel nuclear localizationLocal signalling environments and human male infertility: what we can learn from mouse models.Concerted action of aldehyde dehydrogenases influences depot-specific fat formation.Effect of PITX2 knockdown on transcriptome of primary human trabecular meshwork cell culturesImportance of ALDH1A enzymes in determining human testicular retinoic acid concentrations.Transgenic mouse models for alcohol metabolism, toxicity, and cancer.Alcohol and aldehyde dehydrogenases: retinoid metabolic effects in mouse knockout modelsRDH10 is the primary enzyme responsible for the first step of embryonic Vitamin A metabolism and retinoic acid synthesis.Endogenous retinoids in the hair follicle and sebaceous glandVitamin A in reproduction and developmentDissecting Germ Cell Metabolism through Network ModelingRole of retinoid signaling in the regulation of spermatogenesis.
P2860
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P2860
Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina
description
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Juli 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/07/01)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/07/01)
@nl
наукова стаття, опублікована в липні 2003
@uk
مقالة علمية (نشرت في يوليو 2003)
@ar
name
Targeted disruption of Aldh1a1 ...... hesis in the developing retina
@ast
Targeted disruption of Aldh1a1 ...... hesis in the developing retina
@en
Targeted disruption of Aldh1a1 ...... hesis in the developing retina
@nl
type
label
Targeted disruption of Aldh1a1 ...... hesis in the developing retina
@ast
Targeted disruption of Aldh1a1 ...... hesis in the developing retina
@en
Targeted disruption of Aldh1a1 ...... hesis in the developing retina
@nl
prefLabel
Targeted disruption of Aldh1a1 ...... hesis in the developing retina
@ast
Targeted disruption of Aldh1a1 ...... hesis in the developing retina
@en
Targeted disruption of Aldh1a1 ...... hesis in the developing retina
@nl
P2093
P2860
P3181
P1476
Targeted disruption of Aldh1a1 ...... hesis in the developing retina
@en
P2093
Andrei Molotkov
Arnold E. Cuenca
Christine M. Donmoyer
Louise Deltour
Mario H. Foglio
Shin-Ichi Manabe
Stuart A. Lipton
William S. Blaner
Xiaohong Fan
P2860
P304
P3181
P356
10.1128/MCB.23.13.4637-4648.2003
P407
P577
2003-07-01T00:00:00Z