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Molecular docking studies on interaction of diverse retinol structures with human alcohol dehydrogenases predict a broad role in retinoid ligand synthesisKinetic mechanism of human class IV alcohol dehydrogenase functioning as retinol dehydrogenaseNolz1 promotes striatal neurogenesis through the regulation of retinoic acid signalingNSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signalingStimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3Temporal expression of the human alcohol dehydrogenase gene family during liver development correlates with differential promoter activation by hepatocyte nuclear factor 1Retinoic acid synthesis and signaling during early organogenesisMultiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out miceRetinoic acid regulation of the somitogenesis clockRetinoic acid promotes limb induction through effects on body axis extension but is unnecessary for limb patterningMechanisms of retinoic acid signalling and its roles in organ and limb developmentDistribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brainMetabolic deficiencies in alcohol dehydrogenase Adh1, Adh3, and Adh4 null mutant mice. Overlapping roles of Adh1 and Adh4 in ethanol clearance and metabolism of retinol to retinoic acidRetinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas developmentRetinoic acid controls expression of tissue remodeling genes Hmgn1 and Fgf18 at the digit-interdigit junctionWhole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesisA regulatory network controls nephrocan expression and midgut patterningDose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndromeExcessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3Requirement of mesodermal retinoic acid generated by Raldh2 for posterior neural transformationRetinoic acid synthesis controlled by Raldh2 is required early for limb bud initiation and then later as a proximodistal signal during apical ectodermal ridge formationGenetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acidOpposing actions of cellular retinol-binding protein and alcohol dehydrogenase control the balance between retinol storage and degradationRetinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterningTargeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retinaRole of retinoic acid during forebrain development begins late when Raldh3 generates retinoic acid in the ventral subventricular zoneAldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systemsRaldh2 expression in optic vesicle generates a retinoic acid signal needed for invagination of retina during optic cup formationPatterning of forelimb bud myogenic precursor cells requires retinoic acid signaling initiated by Raldh2Shifting boundaries of retinoic acid activity control hindbrain segmental gene expressionLocalization of class I and class IV alcohol dehydrogenases in mouse testis and epididymis: potential retinol dehydrogenases for endogenous retinoic acid synthesisOrganization of six functional mouse alcohol dehydrogenase genes on two overlapping bacterial artificial chromosomes.In vivo contribution of Class III alcohol dehydrogenase (ADH3) to alcohol metabolism through activation by cytoplasmic solution hydrophobicity.Non-cell-autonomous retinoid signaling is crucial for renal development.Retinoic-acid signalling in node ectoderm and posterior neural plate directs left-right patterning of somitic mesodermThe Xenopus alcohol dehydrogenase gene family: characterization and comparative analysis incorporating amphibian and reptilian genomesDistinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant miceRetinoic acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2Retinoic acid functions as a key GABAergic differentiation signal in the basal ganglia.Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma.
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P50
description
hulumtues
@sq
researcher
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wetenschapper
@nl
հետազոտող
@hy
name
Gregg Duester
@ast
Gregg Duester
@en
Gregg Duester
@es
Gregg Duester
@nl
Gregg Duester
@sl
type
label
Gregg Duester
@ast
Gregg Duester
@en
Gregg Duester
@es
Gregg Duester
@nl
Gregg Duester
@sl
prefLabel
Gregg Duester
@ast
Gregg Duester
@en
Gregg Duester
@es
Gregg Duester
@nl
Gregg Duester
@sl
P108
P106
P21
P31
P496
0000-0003-4335-3650