Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease
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Axonal α7 nicotinic ACh receptors modulate presynaptic NMDA receptor expression and structural plasticity of glutamatergic presynaptic boutonsAlpha7 nicotinic acetylcholine receptor is a target in pharmacology and toxicologyCholinergic imaging in dementia spectrum disordersα7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimumNicotinic ACh receptors as therapeutic targets in CNS disordersAβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic lossThe α7 nicotinic acetylcholine receptor function in hippocampal neurons is regulated by the lipid composition of the plasma membraneLoss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease.Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout miceEvaluating the role of the alpha-7 nicotinic acetylcholine receptor in the pathophysiology and treatment of schizophrenia.Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits.Reduced IGF-1 signaling delays age-associated proteotoxicity in miceA cholinergic trigger drives learning-induced plasticity at hippocampal synapses.Measuring Cortical Connectivity in Alzheimer's Disease as a Brain Neural Network Pathology: Toward Clinical Applications.Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivoComputational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-β on synaptic plasticityCharacterizing ligand-gated ion channel receptors with genetically encoded Ca2++ sensors.The nicotinic acetylcholine receptor: smoking and Alzheimer's disease revisitedγ-Aminobutyric acid type A receptor inhibition triggers a nicotinic neuroprotective mechanism.Virtual screening against acetylcholine binding proteinAlexa Fluor 546-ArIB[V11L;V16A] is a potent ligand for selectively labeling alpha 7 nicotinic acetylcholine receptorsNicotine: specific role in angiogenesis, proliferation and apoptosis.Role of alpha7 nicotinic acetylcholine receptor in calcium signaling induced by prion protein interaction with stress-inducible protein 1.Brain imaging of nicotinic receptors in Alzheimer's disease.α7 Nicotinic Receptor Agonists: Potential Therapeutic Drugs for Treatment of Cognitive Impairments in Schizophrenia and Alzheimer's Disease.Accumulation of intraneuronal β-amyloid 42 peptides is associated with early changes in microtubule-associated protein 2 in neurites and synapses.Models of β-amyloid induced Tau-pathology: the long and "folded" road to understand the mechanism.Rescue of amyloid-Beta-induced inhibition of nicotinic acetylcholine receptors by a peptide homologous to the nicotine binding domain of the alpha 7 subtype.Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.Cancer 'survivor-care': I. the α7 nAChR as potential target for chemotherapy-related cognitive impairment.Design and Synthesis of Nicotinic Acetylcholine Receptor Antagonists and their Effect on Cognitive Impairment.Endogenously released ACh and exogenous nicotine differentially facilitate long-term potentiation induction in the hippocampal CA1 region of mice.Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease.Functional α7 nicotinic ACh receptors on astrocytes in rat hippocampal CA1 slices.Molecular Mechanisms Regulating LPS-Induced Inflammation in the Brain.Effect of Aggregated β-Amyloid (1-42) on Synaptic Plasticity of Hippocampal Dentate Gyrus Granule Cells in Vivo.In vivo pharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain model.Reward learning as a potential target for pharmacological augmentation of cognitive remediation for schizophrenia: a roadmap for preclinical development.Effects of neuronal nicotinic acetylcholine receptor allosteric modulators in animal behavior studies.α7-Containing nicotinic acetylcholine receptors on interneurons of the basolateral amygdala and their role in the regulation of the network excitability
P2860
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P2860
Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Deletion of the alpha 7 nicoti ...... e model of Alzheimer's disease
@ast
Deletion of the alpha 7 nicoti ...... e model of Alzheimer's disease
@en
Deletion of the alpha 7 nicoti ...... e model of Alzheimer's disease
@nl
type
label
Deletion of the alpha 7 nicoti ...... e model of Alzheimer's disease
@ast
Deletion of the alpha 7 nicoti ...... e model of Alzheimer's disease
@en
Deletion of the alpha 7 nicoti ...... e model of Alzheimer's disease
@nl
prefLabel
Deletion of the alpha 7 nicoti ...... e model of Alzheimer's disease
@ast
Deletion of the alpha 7 nicoti ...... e model of Alzheimer's disease
@en
Deletion of the alpha 7 nicoti ...... e model of Alzheimer's disease
@nl
P2093
P2860
P921
P1476
Deletion of the alpha 7 nicoti ...... e model of Alzheimer's disease
@en
P2093
Carolina M Glogowski
Gustavo Dziewczapolski
Stephen F Heinemann
P2860
P304
P356
10.1523/JNEUROSCI.6159-08.2009
P407
P577
2009-07-01T00:00:00Z