BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis - Test2 - elhamkhani - TriplyDB

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

http://www.wikidata.org/entity/Q28607483

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Customizing the genome as therapy for the β-hemoglobinopathies Understanding Spatial Genome Organization: Methods and Insights The therapeutic potential of genome editing for β-thalassemia Genome-editing Technologies for Gene and Cell Therapy Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genome Towards a new era in medicine: therapeutic genome editing Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers.Using CRISPR/Cas to study gene function and model disease in vivo Editing the Neuronal Genome: a CRISPR View of Chromatin Regulation in Neuronal Development, Function, and Plasticity The potential of gene therapy approaches for the treatment of hemoglobinopathies: achievements and challenges The appeasement of Doug: a synthetic approach to enhancer biology.Genome engineering of stem cell organoids for disease modeling.Systematic mapping of functional enhancer-promoter connections with CRISPR interference.What is CRISPR/Cas9?Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening High-resolution interrogation of functional elements in the noncoding genome Mapping regulatory elements.CRISPR library designer (CLD): software for multispecies design of single guide RNA libraries A Molecular Chipper technology for CRISPR sgRNA library generation and functional mapping of noncoding regions Genome-scale CRISPR pooled screens.Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR-Cas9 library.Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.CORALINA: a universal method for the generation of gRNA libraries for CRISPR-based screening HMGA2 Moderately Increases Fetal Hemoglobin Expression in Human Adult Erythroblasts.Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci.Scalable Design of Paired CRISPR Guide RNAs for Genomic Deletion GuideScan software for improved single and paired CRISPR guide RNA design Functional interrogation of non-coding DNA through CRISPR genome editing.CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome.Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition.Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease.A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening.Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.Nucleosomes impede Cas9 access to DNA in vivo and in vitro.Regulation of the fetal hemoglobin silencing factor BCL11A.Recent advances in globin research using genome-wide association studies and gene editing.A CRISPR Path to Engineering New Genetic Mouse Models for Cardiovascular Research A genome editing primer for the hematologist Back to the Future: Mutant Hunts Are Still the Way To Go.Genome editing using CRISPR-Cas9 to create the HPFH genotype in HSPCs: An approach for treating sickle cell disease and β-thalassemia

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P2860

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

http://www.wikidata.org/entity/Q28607483

description

2015 nî lūn-bûn

@nan

2015 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2015年の論文

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2015年論文

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2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

name

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

@ast

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

@en

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

@nl

type

label

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

@ast

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

@en

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

@nl

prefLabel

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

@ast

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

@en

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

@nl

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BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

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Daniel E Bauer

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Diane D Chen

http://www.w3.org/2001/XMLSchema#string

Divya S Vinjamur

http://www.w3.org/2001/XMLSchema#string

Elenoe C Smith

http://www.w3.org/2001/XMLSchema#string

Falak Sher

http://www.w3.org/2001/XMLSchema#string

Feng Zhang

http://www.w3.org/2001/XMLSchema#string

Guo-Cheng Yuan

http://www.w3.org/2001/XMLSchema#string

Ophir Shalem

http://www.w3.org/2001/XMLSchema#string

Ryo Kurita

http://www.w3.org/2001/XMLSchema#string

Stuart H Orkin

http://www.w3.org/2001/XMLSchema#string

P2860

The accessible chromatin landscape of the human genome

RNA-guided human genome engineering via Cas9

Multiplex genome engineering using CRISPR/Cas systems

Histone H3K27ac separates active from poised enhancers and predicts developmental state

THE GROWTH OF BACTERIOPHAGE

ChIP-seq accurately predicts tissue-specific activity of enhancers

Histone modifications at human enhancers reflect global cell-type-specific gene expression

Developmental and species-divergent globin switching are driven by BCL11A

Bcl11a is essential for normal lymphoid development

Mapping and analysis of chromatin state dynamics in nine human cell types

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scholarly article

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2413551

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10.1038/NATURE15521

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7577

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527

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Neville E Sanjana

Matthew C Canver

Patrick G Schupp

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2015-09-16T00:00:00Z

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282039097

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1032459584

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26375006

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