about
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cellsLinear and cooperative signaling: roles for Stat proteins in the regulation of cell survival and apoptosis in the mammary epithelium.STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling.Genetic ablation of Bcl-x attenuates invasiveness without affecting apoptosis or tumor growth in a mouse model of pancreatic neuroendocrine cancerMammary epithelial cells are not able to undergo pregnancy-dependent differentiation in the absence of the helix-loop-helix inhibitor Id2The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regenerationBcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesisThe Stat3/5 locus encodes novel endoplasmic reticulum and helicase-like proteins that are preferentially expressed in normal and neoplastic mammary tissueDistinct tyrosine residues within the interleukin-2 receptor beta chain drive signal transduction specificity, redundancy, and diversityAcute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland functionSTAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System.The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis.Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of PtenTumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesityFunctional assessment of CTCF sites at cytokine-sensing mammary enhancers using CRISPR/Cas9 gene editing in miceCRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome.Trp63 is regulated by STAT5 in mammary tissue and subject to differentiation in cancer.Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias.Cytokine-regulated GADD45G induces differentiation and lineage selection in hematopoietic stem cells.The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responsesAbsence of STAT1 in donor-derived plasmacytoid dendritic cells results in increased STAT3 and attenuates murine GVHDThe gene encoding the hematopoietic stem cell regulator CCN3/NOV is under direct cytokine control through the transcription factors STAT5A/B.Loss of STAT1 from mouse mammary epithelium results in an increased Neu-induced tumor burden.Experimental mouse genetics-- answering fundamental questions about mammary gland biology.Signaling pathways in mammary gland development.Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues.Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.Comprehensive meta-analysis of Signal Transducers and Activators of Transcription (STAT) genomic binding patterns discerns cell-specific cis-regulatory modulesHelper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals.The STAT5-regulated miR-193b locus restrains mammary stem and progenitor cell activity and alveolar differentiation.The methyltransferase EZH2 is not required for mammary cancer development, although high EZH2 and low H3K27me3 correlate with poor prognosis of ER-positive breast cancersComparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance.Direct activation of STAT5 by ETV6-LYN fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis.The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expressionComparative sequence analysis of the mRNAs coding for mouse and rat whey protein.Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locusTemporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression
P50
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P50
description
researcher
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wetenschapper
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հետազոտող
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name
Lothar Hennighausen
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Lothar Hennighausen
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Lothar Hennighausen
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Lothar Hennighausen
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Lothar Hennighausen
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type
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Lothar Hennighausen
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Lothar Hennighausen
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Lothar Hennighausen
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Lothar Hennighausen
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Lothar Hennighausen
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prefLabel
Lothar Hennighausen
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Lothar Hennighausen
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Lothar Hennighausen
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Lothar Hennighausen
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Lothar Hennighausen
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P106
P1153
56233898200
P31
P496
0000-0001-8319-9841