MDM2 and MDMX: Alone and together in regulation of p53 - Test2 - elhamkhani - TriplyDB

MDM2 and MDMX: Alone and together in regulation of p53

MDM2 and MDMX: Alone and together in regulation of p53

http://www.wikidata.org/entity/Q28611422

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Clinical Overview of MDM2/X-Targeted Therapies The functional diversity of protein lysine methylation Localization and interactions of Plasmodium falciparum SWIB/MDM2 homologues Motif mediated protein-protein interactions as drug targets Systems biology analysis reveals role of MDM2 in diabetic nephropathy ATM Signaling Pathway Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis.p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization.p53 protects against LPS-induced lung endothelial barrier dysfunction.ASPP2 involvement in p53-mediated HIV-1 envelope glycoprotein gp120 neurotoxicity in mice cerebrocortical neurons.MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability.TP53 supports basal-like differentiation of mammary epithelial cells by preventing translocation of deltaNp63 into nucleoli.Amplification of Mdmx and overexpression of MDM2 contribute to mammary carcinogenesis by substituting for p53 mutations.Ionizing radiation-induced responses in human cells with differing TP53 status.AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX-MDM2 complex.Identification of Kaposi Sarcoma Herpesvirus (KSHV) vIRF1 Protein as a Novel Interaction Partner of Human Deubiquitinase USP7.NEDD4 is involved in acquisition of epithelial-mesenchymal transition in cisplatin-resistant nasopharyngeal carcinoma cells.Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry.Aryl hydrocarbon receptor (AHR): "pioneer member" of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of "sensors" of foreign and endogenous signals.Guilty as CHARGED: p53's expanding role in disease.Human epidermal growth factor receptor 4 (Her4) Suppresses p53 Protein via Targeting the MDMX-MDM2 Protein Complex: IMPLICATION OF A NOVEL MDMX SER-314 PHOSPHOSITE.The Role of MDM2 in Promoting Genome Stability versus Instability.MDM2 promotes epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells.Inhibition of NEDD4 inhibits cell growth and invasion and induces cell apoptosis in bladder cancer cells.Alterations in expression levels of genes in p53-related pathways determined using RNA-Seq analysis in patients with breast cancer following CIK therapy.Inhibition of Mdmx (Mdm4) in vivo induces anti-obesity effects.Monitoring p53 by MDM2 and MDMX is required for endocrine pancreas development and function in a spatio-temporal manner.The Roles of MDM2 and MDMX in Cancer.MDMX under stress: the MDMX-MDM2 complex as stress signals hub

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MDM2 and MDMX: Alone and together in regulation of p53

http://www.wikidata.org/entity/Q28611422

description

2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2012

@ast

scientific journal article

@en

vedecký článok (publikovaný 2012/08/01)

@sk

vědecký článek publikovaný v roce 2012

@cs

wetenschappelijk artikel (gepubliceerd op 2012/08/01)

@nl

wissenschaftlicher Artikel

@de

наукова стаття, опублікована в серпні 2012

@uk

مقالة علمية (نشرت في أغسطس 2012)

@ar

name

MDM2 and MDMX: Alone and together in regulation of p53

@ast

MDM2 and MDMX: Alone and together in regulation of p53

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MDM2 and MDMX: Alone and together in regulation of p53

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type

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MDM2 and MDMX: Alone and together in regulation of p53

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MDM2 and MDMX: Alone and together in regulation of p53

@en

MDM2 and MDMX: Alone and together in regulation of p53

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prefLabel

MDM2 and MDMX: Alone and together in regulation of p53

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MDM2 and MDMX: Alone and together in regulation of p53

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MDM2 and MDMX: Alone and together in regulation of p53

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Translational cancer research

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MDM2 and MDMX: Alone and together in regulation of p53

@en

P2093

Miriam Shadfan

http://www.w3.org/2001/XMLSchema#string

Vanessa Lopez-Pajares

http://www.w3.org/2001/XMLSchema#string

Zhi-Min Yuan

http://www.w3.org/2001/XMLSchema#string

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Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

Monoubiquitylation promotes mitochondrial p53 translocation

Turning the RING domain protein MdmX into an active ubiquitin-protein ligase

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.

Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2

Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.

14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation

Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding

Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase

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88–89

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scholarly article

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3535624

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2012-08-01T00:00:00Z

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23002429

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3448287

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