Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
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The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradationMdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosisRegulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activationPhosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 bindingMdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligaseMDMX regulation of p53 response to ribosomal stressAn essential function of the extreme C-terminus of MDM2 can be provided by MDMXMDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathwayDNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation.DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms.HECT and RING finger families of E3 ubiquitin ligases at a glanceRibosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathwayAlterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53Ribosomal proteins as unrevealed caretakers for cellular stress and genomic instabilityDeubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in transMDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblastsMdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitinationMdmX binding to ARF affects Mdm2 protein stability and p53 transactivationMutual dependence of MDM2 and MDMX in their functional inactivation of p53Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 proteinHdmx modulates the outcome of p53 activation in human tumor cellsActivation and activities of the p53 tumour suppressor proteinEstablishment of a Wheat Cell-Free Synthesized Protein Array Containing 250 Human and Mouse E3 Ubiquitin Ligases to Identify Novel Interaction between E3 Ligases and Substrate ProteinsMDM2 and MDMX: Alone and together in regulation of p53Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer.MDM4 (MDMX) and its Transcript Variants.Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis.An observational study on the expression levels of MDM2 and MDMX proteins, and associated effects on P53 in a series of human liposarcomasAchieving cell penetration with distance-matching cysteine cross-linkers: a facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx.The regulation of the p53-mediated stress response by MDM2 and MDM4.MiR-766 induces p53 accumulation and G2/M arrest by directly targeting MDM4.MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer.microRNAs and Alu elements in the p53-Mdm2-Mdm4 regulatory network.MDM2 oligomers: antagonizers of the guardian of the genome.Regulation of p53-MDMX interaction by casein kinase 1 alpha.Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development.Doxorubicin and 5-fluorouracil induced accumulation and transcriptional activity of p53 are independent of the phosphorylation at serine 15 in MCF-7 breast cancer cells
P2860
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P248
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P2860
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Stabilization of the MDM2 onco ...... ucturally related MDMX protein
@ast
Stabilization of the MDM2 onco ...... ucturally related MDMX protein
@en
Stabilization of the MDM2 onco ...... ucturally related MDMX protein
@en-gb
Stabilization of the MDM2 onco ...... ucturally related MDMX protein
@nl
type
label
Stabilization of the MDM2 onco ...... ucturally related MDMX protein
@ast
Stabilization of the MDM2 onco ...... ucturally related MDMX protein
@en
Stabilization of the MDM2 onco ...... ucturally related MDMX protein
@en-gb
Stabilization of the MDM2 onco ...... ucturally related MDMX protein
@nl
prefLabel
Stabilization of the MDM2 onco ...... ucturally related MDMX protein
@ast
Stabilization of the MDM2 onco ...... ucturally related MDMX protein
@en
Stabilization of the MDM2 onco ...... ucturally related MDMX protein
@en-gb
Stabilization of the MDM2 onco ...... ucturally related MDMX protein
@nl
P2093
P2860
P921
P3181
P356
P1476
Stabilization of the MDM2 onco ...... ucturally related MDMX protein
@en
P2093
D L George
S A Kratowicz
P2860
P304
P3181
P356
10.1074/JBC.274.53.38189
P407
P577
1999-12-31T00:00:00Z