Plasminogen activation initiated by single-chain urokinase-type plasminogen activator. Potentiation by U937 monocytes
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Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysisCrystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptideDirect binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activityCell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinasesThe receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexesMannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interactionRibosome-inactivating proteins: from plant defense to tumor attackSingle amino acid substitutions in the chemotactic sequence of urokinase receptor modulate cell migration and invasionStructure-based Engineering of Species Selectivity in the Interaction between Urokinase and Its Receptor: IMPLICATION FOR PRECLINICAL CANCER THERAPYMyosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner.Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammationPlasmin promotes foam cell formation by increasing macrophage catabolism of aggregated low-density lipoprotein.Probing binding and cellular activity of pyrrolidinone and piperidinone small molecules targeting the urokinase receptor.A ligand-free, soluble urokinase receptor is present in the ascitic fluid from patients with ovarian cancer.The plasminogen activator/plasmin systemCell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cellsHuman retinal pigment epithelial lysis of extracellular matrix: functional urokinase plasminogen activator receptor, collagenase, and elastaseSerum-stable RNA aptamers to urokinase-type plasminogen activator blocking receptor binding.Protease nexin-1 expression is altered in human breast cancer.A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection.Plasminogen mediates the pathological effects of urokinase-type plasminogen activator overexpressionMis-trafficking of endosomal urokinase proteins triggers drug-induced glioma nonapoptotic cell death.Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction.A new class of orthosteric uPAR·uPA small-molecule antagonists are allosteric inhibitors of the uPAR·vitronectin interactionEndogenously generated plasmin at the vascular wall injury site amplifies lysine binding site-dependent plasminogen accumulation in microthrombi.Cellular distribution and clinical value of urokinase-type plasminogen activator, its receptor, and plasminogen activator inhibitor-2 in esophageal squamous cell carcinoma.Urokinase receptor is a multifunctional protein: influence of receptor occupancy on macrophage gene expressionPorphyromonas gingivalis-derived RgpA-Kgp Complex Activates the Macrophage Urokinase Plasminogen Activator System: IMPLICATIONS FOR PERIODONTITISCathepsin B and other proteases in human colorectal carcinoma.Copper-dependent degradation of the Saccharomyces cerevisiae plasma membrane copper transporter Ctr1p in the apparent absence of endocytosis.Enhanced expression of urokinase plasminogen activator and its receptor in pancreatic carcinoma.Increased soluble urokinase plasminogen activator receptor (suPAR) is associated with thrombosis and inhibition of plasmin generation in paroxysmal nocturnal hemoglobinuria (PNH) patientsPlasmin triggers a switch-like decrease in thrombospondin-dependent activation of TGF-β1.alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptorReceptor-independent role of urokinase-type plasminogen activator in pericellular plasmin and matrix metalloproteinase proteolysis during vascular wound healing in mice.The urokinase-type plasminogen activator receptor, a GPI-linked protein, is localized in caveolae.Expression of the urokinase receptor in vascular endothelial cells is stimulated by basic fibroblast growth factor.LRP-1 silencing prevents malignant cell invasion despite increased pericellular proteolytic activitiesA CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo.Lysosomal degradation of receptor-bound urokinase-type plasminogen activator is enhanced by its inhibitors in human trophoblastic choriocarcinoma cells.
P2860
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P2860
Plasminogen activation initiated by single-chain urokinase-type plasminogen activator. Potentiation by U937 monocytes
description
1989 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1989
@ast
im Februar 1989 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1989/02/05)
@sk
vědecký článek publikovaný v roce 1989
@cs
wetenschappelijk artikel (gepubliceerd op 1989/02/05)
@nl
наукова стаття, опублікована в лютому 1989
@uk
name
Plasminogen activation initiat ...... Potentiation by U937 monocytes
@ast
Plasminogen activation initiat ...... Potentiation by U937 monocytes
@en
Plasminogen activation initiat ...... Potentiation by U937 monocytes
@nl
type
label
Plasminogen activation initiat ...... Potentiation by U937 monocytes
@ast
Plasminogen activation initiat ...... Potentiation by U937 monocytes
@en
Plasminogen activation initiat ...... Potentiation by U937 monocytes
@nl
prefLabel
Plasminogen activation initiat ...... Potentiation by U937 monocytes
@ast
Plasminogen activation initiat ...... Potentiation by U937 monocytes
@en
Plasminogen activation initiat ...... Potentiation by U937 monocytes
@nl
P2093
P1476
Plasminogen activation initiat ...... Potentiation by U937 monocytes
@en
P2093
M. F. Scully
V. V. Kakkar
P304
P407
P577
1989-02-05T00:00:00Z