Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease - Test2 - elhamkhani - TriplyDB

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease

http://www.wikidata.org/entity/Q28748461

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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease Gene Prioritization for Imaging Genetics Studies Using Gene Ontology and a Stratified False Discovery Rate Approach Differential expression of CD300a/c on human TH1 and TH17 cells ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models The amyloid hypothesis of Alzheimer's disease at 25 years Alzheimer's Disease: Mechanism and Approach to Cell Therapy Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.Genomic variants, genes, and pathways of Alzheimer's disease: An overview.Integrating Genome-Wide Association Study and Brain Expression Data Highlights Cell Adhesion Molecules and Purine Metabolism in Alzheimer's Disease.Pathway analysis of genome-wide association study and transcriptome data highlights new biological pathways in colorectal cancer.Convergent genetic and expression data implicate immunity in Alzheimer's disease Genetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease risk.Powerful and Adaptive Testing for Multi-trait and Multi-SNP Associations with GWAS and Sequencing Data.Metaflammasome components in the human brain: a role in dementia with Alzheimer's pathology?Genetic architectures of psychiatric disorders: the emerging picture and its implications.The CD300 molecules: an emerging family of regulators of the immune system.Data mining of high density genomic variant data for prediction of Alzheimer's disease risk Functional requirements for inhibitory signal transmission by the immunomodulatory receptor CD300a.Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease.Pathway analysis of smoking quantity in multiple GWAS identifies cholinergic and sensory pathways.The impact of human and mouse differences in NOS2 gene expression on the brain's redox and immune environment.Mitotic spindle defects and chromosome mis-segregation induced by LDL/cholesterol-implications for Niemann-Pick C1, Alzheimer's disease, and atherosclerosis.Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk.Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease.Post-mortem analysis of neuroinflammatory changes in human Alzheimer's disease.ENU mutagenesis screen to establish motor phenotypes in wild-type mice and modifiers of a pre-existing motor phenotype in tau mutant mice.Alzheimer's Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System The Fox and the Rabbits-Environmental Variables and Population Genetics (1) Replication Problems in Association Studies and the Untapped Power of GWAS (2) Vitamin A Deficiency, Herpes Simplex Reactivation and Other Causes of Alzheimer's Disease Pathway-Wide Association Study Implicates Multiple Sterol Transport and Metabolism Genes in HDL Cholesterol Regulation.Variations in the FRA10AC1 Fragile Site and 15q21 Are Associated with Cerebrospinal Fluid Aβ1-42 Level.A-Subclass ATP-Binding Cassette Proteins in Brain Lipid Homeostasis and Neurodegeneration.An adaptive genetic algorithm for selection of blood-based biomarkers for prediction of Alzheimer's disease progression Role of Liver X Receptor in AD Pathophysiology.Genome-wide and gene-based association implicates FRMD6 in Alzheimer disease.Similarity-based multimarker association tests for continuous traits.Pathway analysis of body mass index genome-wide association study highlights risk pathways in cardiovascular disease.Permutation-based approaches do not adequately allow for linkage disequilibrium in gene-wide multi-locus association analysis.GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP.Does ionizing radiation influence Alzheimer's disease risk?

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Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease

http://www.wikidata.org/entity/Q28748461

description

2010 nî lūn-bûn

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2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Genetic evidence implicates th ...... tiology of Alzheimer's disease

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Genetic evidence implicates th ...... tiology of Alzheimer's disease

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Genetic evidence implicates th ...... tiology of Alzheimer's disease

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Genetic evidence implicates th ...... tiology of Alzheimer's disease

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Alexandra Stretton

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Amy Gerrish

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P2860

Cholinesterase inhibitors for Alzheimer's disease

Role of Genes and Environments for Explaining Alzheimer Disease

Alzheimer Disease in the US Population

From genomics to chemical genomics: new developments in KEGG

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk

ApoE promotes the proteolytic degradation of Abeta

PLINK: a tool set for whole-genome association and population-based linkage analyses

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47812859

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21085570

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Alzheimer's disease

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