Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron
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Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agentsUsing CellMiner 1.6 for Systems Pharmacology and Genomic Analysis of the NCI-60Using drug response data to identify molecular effectors, and molecular "omic" data to identify candidate drugs in cancerReconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancerIdentification of a predominant co-regulation among kinetochore genes, prospective regulatory elements, and association with genomic instabilityBreakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer typesNCI-60 whole exome sequencing and pharmacological CellMiner analysesHigh resolution copy number variation data in the NCI-60 cancer cell lines from whole genome microarrays accessible through CellMinerGenome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisonsThe structure–activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding modeFunctional categories associated with clusters of genes that are co-expressed across the NCI-60 cancer cell linesIdentification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interactionProtein kinase CK2 is a central regulator of topoisomerase I hyperphosphorylation and camptothecin sensitivity in cancer cell linesG4 motifs correlate with promoter-proximal transcriptional pausing in human genes.Coordinated regulation of mitochondrial topoisomerase IB with mitochondrial nuclear encoded genes and MYC.CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set.Topoisomerase I copy number alterations as biomarker for irinotecan efficacy in metastatic colorectal cancer.Improved large-scale prediction of growth inhibition patterns using the NCI60 cancer cell line panel.Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevanceComputational selection of antibody-drug conjugate targets for breast cancer.Personalized Prediction of Proliferation Rates and Metabolic Liabilities in Cancer Biopsies.G-quadruplexes: targets and tools in anticancer drug design.G-quadruplex-induced instability during leading-strand replication.Thioflavin T as a fluorescence light-up probe for G4 formation.TOP1 gene copy numbers in colorectal cancer samples and cell lines and their association to in vitro drug sensitivity.CHEK2 genomic and proteomic analyses reveal genetic inactivation or endogenous activation across the 60 cell lines of the US National Cancer Institute.DNA molecular recognition and cellular selectivity of anticancer metal(II) complexes of ethylenediaminediacetate and phenanthroline: multiple targets.Topoisomerase-1 gene copy aberrations are frequent in patients with breast cancer.Myoblast Myogenic Differentiation but Not Fusion Process Is Inhibited via MyoD Tetraplex Interaction.Loss of GCNT2/I-branched glycans enhances melanoma growth and survivalAggregating distyrylpyridinium dye as a bimodal structural probe for G-quadruplex DNA
P2860
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P2860
Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron
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2010年の論文
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2010年論文
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2010年論文
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2010年論文
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Exon array analyses across the ...... e quartets in the first intron
@ast
Exon array analyses across the ...... e quartets in the first intron
@en
Exon array analyses across the ...... e quartets in the first intron
@nl
type
label
Exon array analyses across the ...... e quartets in the first intron
@ast
Exon array analyses across the ...... e quartets in the first intron
@en
Exon array analyses across the ...... e quartets in the first intron
@nl
prefLabel
Exon array analyses across the ...... e quartets in the first intron
@ast
Exon array analyses across the ...... e quartets in the first intron
@en
Exon array analyses across the ...... e quartets in the first intron
@nl
P2093
P2860
P1433
P1476
Exon array analyses across the ...... e quartets in the first intron
@en
P2093
Hongfang Liu
James Doroshow
John N Weinstein
Michael Ryan
Ralph Parchment
Robert Kinders
Thomas D Pfister
William C Reinhold
P2860
P304
P356
10.1158/0008-5472.CAN-09-3528
P407
P577
2010-03-15T00:00:00Z