Dissecting FMR1, the protein responsible for fragile X syndrome, in its structural and functional domains
about
A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2PDendritic BC1 RNA in translational control mechanismsRNAi-mediated depletion of the 15 KH domain protein, vigilin, induces death of dividing and non-dividing human cells but does not initially inhibit protein synthesisA new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stabilityA novel function for fragile X mental retardation protein in translational activationFragile X mental retardation protein FMRP binds mRNAs in the nucleusFrom mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndromeThe fragile X mental retardation protein inhibits translation via interacting with mRNAThe GABAA receptor is an FMRP target with therapeutic potential in fragile X syndrome.Arginines of the RGG box regulate FMRP association with polyribosomes and mRNA.The fragile X mental retardation protein and group I metabotropic glutamate receptors regulate levels of mRNA granules in brain.FMR1 gene and fragile X syndrome.The role of a clinically important mutation in the fold and RNA-binding properties of KH motifsG-quartet-dependent recognition between the FMRP RGG box and RNA.Increasing our understanding of human cognition through the study of Fragile X Syndrome.Fragile X mental retardation protein in plasticity and disease.Human FMRP contains an integral tandem Agenet (Tudor) and KH motif in the amino terminal domain.Substitution of critical isoleucines in the KH domains of Drosophila fragile X protein results in partial loss-of-function phenotypes.BC1-FMRP interaction is modulated by 2'-O-methylation: RNA-binding activity of the tudor domain and translational regulation at synapsesFunctional overlap between conserved and diverged KH domains in Saccharomyces cerevisiae SCP160.FMRP RNA targets: identification and validation.The HSV-1 ICP27 RGG box specifically binds flexible, GC-rich sequences but not G-quartet structuresFragile X-associated disorders: a clinical overview.A structural perspective of RNA recognition by intrinsically disordered proteins.Conformational-dependent and independent RNA binding to the fragile x mental retardation protein.The RNA binding domains of the nuclear poly(A)-binding protein.Reduced Levels of the Synaptic Functional Regulator FMRP in Dentate Gyrus of the Aging Sprague-Dawley Rat.Molecular dynamics simulations show how the FMRP Ile304Asn mutation destabilizes the KH2 domain structure and affects its function.Fragile X mental retardation protein (FMRP) binds specifically to the brain cytoplasmic RNAs BC1/BC200 via a novel RNA-binding motif.The DEAD-box protein DDX43 (HAGE) is a dual RNA-DNA helicase and has a K-homology domain required for full nucleic acid unwinding activity.Regulation of Adult Neurogenesis by the Fragile X Family of RNA Binding Proteins
P2860
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P2860
Dissecting FMR1, the protein responsible for fragile X syndrome, in its structural and functional domains
description
1999 nî lūn-bûn
@nan
1999 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Dissecting FMR1, the protein r ...... uctural and functional domains
@ast
Dissecting FMR1, the protein r ...... uctural and functional domains
@en
type
label
Dissecting FMR1, the protein r ...... uctural and functional domains
@ast
Dissecting FMR1, the protein r ...... uctural and functional domains
@en
prefLabel
Dissecting FMR1, the protein r ...... uctural and functional domains
@ast
Dissecting FMR1, the protein r ...... uctural and functional domains
@en
P2093
P2860
P1433
P1476
Dissecting FMR1, the protein r ...... uctural and functional domains
@en
P2093
P2860
P304
P356
10.1017/S1355838299990647
P407
P577
1999-09-01T00:00:00Z