Yeast as a model of human mitochondrial tRNA base substitutions: investigation of the molecular basis of respiratory defects

Yeast as a model of human mitochondrial tRNA base substitutions: investigation of the molecular basis of respiratory defects

Item
http://www.wikidata.org/entity/Q29048147
Q29048158
sameAs
Identification of lethal mutations in yeast threonyl-tRNA synthetase revealing critical residues in its human homolog.Structural and functional role of bases 32 and 33 in the anticodon loop of yeast mitochondrial tRNAIleYeast as a system for modeling mitochondrial disease mechanisms and discovering therapies.Screening of effective pharmacological treatments for MELAS syndrome using yeasts, fibroblasts and cybrid models of the diseaseThe power of yeast to model diseases of the powerhouse of the cell.Peptides from aminoacyl-tRNA synthetases can cure the defects due to mutations in mt tRNA genes.Higher order structural effects stabilizing the reverse Watson-Crick Guanine-Cytosine base pair in functional RNAs.Overexpression of mitochondrial oxodicarboxylate carrier (ODC1) preserves oxidative phosphorylation in a yeast model of Barth syndrome.Strain-specific nuclear genetic background differentially affects mitochondria-related phenotypes in Saccharomyces cerevisiaemt-tRNA components: synthesis of (2-thio)uridines modified with blocked glycine/taurine moieties at C-5,1.
P2860

Yeast as a model of human mitochondrial tRNA base substitutions: investigation of the molecular basis of respiratory defects

Item
http://www.wikidata.org/entity/Q29048147
description
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im Februar 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: February 2008)
@en
wetenschappelijk artikel (gepubliceerd in 2008-02)
@nl
наукова стаття, опублікована в лютому 2008
@uk
مقالة علمية (نشرت في فبراير 2008)
@ar
name
Yeast as a model of human mito ...... r basis of respiratory defects
@ast
Yeast as a model of human mito ...... r basis of respiratory defects
@en
type
label
Yeast as a model of human mito ...... r basis of respiratory defects
@ast
Yeast as a model of human mito ...... r basis of respiratory defects
@en
prefLabel
Yeast as a model of human mito ...... r basis of respiratory defects
@ast
Yeast as a model of human mito ...... r basis of respiratory defects
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P932
P356
P1433
P1476
Yeast as a model of human mito ...... r basis of respiratory defects
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P932