Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes - Test2 - elhamkhani - TriplyDB

Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes

Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes

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Building Bridges: Biocatalytic C–C-Bond Formation toward Multifunctional Products Accessing Nature's diversity through metabolic engineering and synthetic biology Protein design: toward functional metalloenzymes Expanding P450 catalytic reaction space through evolution and engineering A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo Key Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate Bias The role of distant mutations and allosteric regulation on LovD active site dynamics Human P450-like oxidation of diverse proton pump inhibitor drugs by 'gatekeeper' mutants of flavocytochrome P450 BM3 Advances in the directed evolution of proteins.A novel tyrosine-heme C−O covalent linkage in F43Y myoglobin: a new post-translational modification of heme proteins A designed supramolecular protein assembly with in vivo enzymatic activity How a novel tyrosine-heme cross-link fine-tunes the structure and functions of heme proteins: a direct comparitive study of L29H/F43Y myoglobin Catalytic Promiscuity of Transaminases: Preparation of Enantioenriched β-Fluoroamines by Formal Tandem Hydrodefluorination/Deamination Directed evolution of artificial metalloenzymes for in vivo metathesis A roadmap for biocatalysis - functional and spatial orchestration of enzyme cascades Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450.Beyond Iron: Iridium-Containing P450 Enzymes for Selective Cyclopropanations of Structurally Diverse Alkenes.Improved cyclopropanation activity of histidine-ligated cytochrome P450 enables the enantioselective formal synthesis of levomilnacipran Enantioselective imidation of sulfides via enzyme-catalyzed intermolecular nitrogen-atom transfer P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins under aerobic conditions.Regio- and stereoselective hydroxylation of 10-undecenoic acid with a light-driven P450 BM3 biocatalyst yielding a valuable synthon for natural product synthesis.Opportunities for merging chemical and biological synthesis Enzyme-controlled nitrogen-atom transfer enables regiodivergent C-H amination.Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates.Non-natural olefin cyclopropanation catalyzed by diverse cytochrome P450s and other hemoproteins.Expanding the enzyme universe: accessing non-natural reactions by mechanism-guided directed evolution.Enzymatic C(sp(3))-H Amination: P450-Catalyzed Conversion of Carbonazidates into Oxazolidinones.Combinatorial library based engineering of Candida antarctica lipase A for enantioselective transacylation of sec-alcohols in organic solvent.Regulating the coordination state of a heme protein by a designed distal hydrogen-bonding network.Highly diastereoselective and enantioselective olefin cyclopropanation using engineered myoglobin-based catalysts.Intermolecular carbene S-H insertion catalysed by engineered myoglobin-based catalysts†.Catalytic and Biocatalytic Iron Porphyrin Carbene Formation: Effects of Binding Mode, Carbene Substituent, Porphyrin Substituent, and Protein Axial Ligand.Substrate Hunting for the Myxobacterial CYP260A1 Revealed New 1α-Hydroxylated Products from C-19 Steroids.Interfacing microbial styrene production with a biocompatible cyclopropanation reaction High-throughput analysis and protein engineering using microcapillary arrays.Synthesis of 1-Naphthol by a Natural Peroxygenase Engineered by Directed Evolution.Photocatalytic Oxygenation of Substrates by Dioxygen with Protonated Manganese(III) Corrolazine.Whole-cell microtiter plate screening assay for terminal hydroxylation of fatty acids by P450s.Expanding an Efficient, Electrically Driven and CNT-Tagged P450 System into the Third Dimension: A Nanowired CNT-Containing and Enzyme-Stabilising 3 D Sol-Gel Electrode.

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Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes

http://www.wikidata.org/entity/Q29395910

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2012 nî lūn-bûn

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2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Olefin Cyclopropanation via Ca ...... neered Cytochrome P450 Enzymes

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Olefin Cyclopropanation via Ca ...... neered Cytochrome P450 Enzymes

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Olefin Cyclopropanation via Ca ...... neered Cytochrome P450 Enzymes

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SCIENCE.1231434

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Olefin Cyclopropanation via Ca ...... neered Cytochrome P450 Enzymes

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A. Kannan

http://www.w3.org/2001/XMLSchema#string

E. M. Brustad

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F. H. Arnold

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P. S. Coelho

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P2860

Structure-guided recombination creates an artificial family of cytochromes P450.

Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s

Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

Stereoselective cyclopropanation reactions

Evolutionary history of a specialized p450 propane monooxygenase

Catalytic C–H functionalization by metal carbenoid and nitrenoid insertion

Biosynthesis and Metabolism of Cyclopropane Rings in Natural Compounds

The bioinorganic chemistry of iron in oxygenases and supramolecular assemblies.

Combinatorial alanine substitution enables rapid optimization of cytochrome P450BM3 for selective hydroxylation of large substrates.

Enzyme promiscuity: evolutionary and mechanistic aspects.

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307-310

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scholarly article

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819820

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10.1126/SCIENCE.1231434

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6117

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339

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2012-12-20T00:00:00Z

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23258409

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