Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s
about
In the light of directed evolution: pathways of adaptive protein evolutionExploring protein fitness landscapes by directed evolutionSelective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenaseExpanding the repertoire of biofuel alternatives through metabolic pathway evolutionOlefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 EnzymesNeutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution.SCHEMA computational design of virus capsid chimeras: calibrating how genome packaging, protection, and transduction correlate with calculated structural disruption.Identification of mutant Asp251Gly/Gln307His of cytochrome P450 BM3 for the generation of metabolites of diclofenac, ibuprofen and tolbutamide.Random field model reveals structure of the protein recombinational landscape.A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds.Discriminating between stabilizing and destabilizing protein design mutations via recombination and simulation.Navigating the protein fitness landscape with Gaussian processesDirected enzyme evolution: climbing fitness peaks one amino acid at a time.P450(BM3) (CYP102A1): connecting the dots.Chimeric P450 enzymes: activity of artificial redox fusions driven by different reductases for biotechnological applications.Recent advances in rational approaches for enzyme engineering.The application of engineered liver tissues for novel drug discovery.Improving artificial metalloenzymes' activity by optimizing electron transfer.High-throughput functional screening of steroid substrates with wild-type and chimeric P450 enzymes.Understanding Flavin-Dependent Halogenase Reactivity via Substrate Activity Profiling.A divide-and-conquer approach to determine the Pareto frontier for optimization of protein engineering experimentsAntibody engineering and therapeutics, The Annual Meeting of the Antibody Society: December 8-12, 2013, Huntington Beach, CAScreening for cytochrome p450 reactivity by harnessing catalase as reporter enzyme.Chimeric cytochromes P450 engineered by domain swapping and random mutagenesis for producing human metabolites of drugs.Creating protein biocatalysts as tools for future industrial applicationsBiochemie 2009
P2860
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P2860
Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s
description
2007 nî lūn-bûn
@nan
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
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2007年の論文
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2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s
@ast
Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s
@en
Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s
@nl
type
label
Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s
@ast
Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s
@en
Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s
@nl
prefLabel
Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s
@ast
Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s
@en
Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s
@nl
P2093
P2860
P1476
Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s
@en
P2093
Christopher R Otey
Marco Landwehr
Martina Carbone
P2860
P304
P356
10.1016/J.CHEMBIOL.2007.01.009
P407
P577
2007-03-01T00:00:00Z