Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
about
A comprehensive resource of interacting protein regions for refining human transcription factor networksIdentification of protein interactions involved in cellular signalingTRIP Database: a manually curated database of protein-protein interactions for mammalian TRP channelsPCRPi-DB: a database of computationally annotated hot spots in protein interfacesStructural conservation of druggable hot spots in protein-protein interfacesSmall-molecule inhibition of BRDT for male contraception.A comprehensive manually curated protein-protein interaction database for the Death Domain superfamilySmall molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interactionThe impact of GPCR structures on pharmacology and structure-based drug designSystematic analysis of helical protein interfaces reveals targets for synthetic inhibitorsIntrinsically disordered proteins are potential drug targetsCompstatin: a complement inhibitor on its way to clinical applicationProcess of Fragment-Based Lead Discovery-A Perspective from NMRMolecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling UnitsTargeting protein-protein interactions in complexes organized by A kinase anchoring proteinsDirect and Propagated Effects of Small Molecules on Protein-Protein Interaction NetworksMolecular docking and structure-based drug design strategiesEvolution of Macromolecular Docking Techniques: The Case Study of Nickel and Iron Metabolism in Pathogenic BacteriaFine-tuning multiprotein complexes using small moleculesSurfing the Protein-Protein Interaction Surface Using Docking Methods: Application to the Design of PPI InhibitorsNuclear receptor coregulators: modulators of pathology and therapeutic targetsFeatures of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinityHistone-modifying enzymes, histone modifications and histone chaperones in nucleosome assembly: Lessons learned from Rtt109 histone acetyltransferasesStructure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive reviewHDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?Characterizing the dynamics of proteasome complexes by proteomics approachesThe Role of Medical Structural Genomics in Discovering New Drugs for Infectious DiseasesStructure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar AffinitiesSimultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat proteinCombinatorial Optimization of a CD4-Mimetic Miniprotein and Cocrystal Structures with HIV-1 gp120 Envelope GlycoproteinElectrostatic contributions drive the interaction betweenStaphylococcus aureusprotein Efb-C and its complement target C3dCortisone dissociates the Shaker family K+ channels from their β subunitsCrystal Structure and Carbohydrate Analysis of Nipah Virus Attachment Glycoprotein: a Template for Antiviral and Vaccine DesignThe interaction of CK2α and CK2β, the subunits of protein kinase CK2, requires CK2β in a preformed conformation and is enthalpically drivenMolecular Shape and Medicinal Chemistry: A PerspectiveDimeric Architecture of the Hendra Virus Attachment Glycoprotein: Evidence for a Conserved Mode of AssemblyLimitations of Peptide Retro-inverso Isomerization in Molecular MimicryA Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In VivoIdentification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactionsX-ray Crystal Structures of Monomeric and Dimeric Peptide Inhibitors in Complex with the Human Neonatal Fc Receptor, FcRn
P2860
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P2860
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
description
2007 nî lūn-bûn
@nan
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
@ast
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
@en
type
label
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
@ast
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
@en
prefLabel
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
@ast
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
@en
P3181
P356
P1433
P1476
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
@en
P2093
McClendon CL
P2888
P304
P3181
P356
10.1038/NATURE06526
P407
P577
2007-12-13T00:00:00Z
P5875
P6179
1038231590