Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins - Test2 - elhamkhani - TriplyDB

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

http://www.wikidata.org/entity/Q29547593

about

Transthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid.Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study.New Class of Inhibitors of Amyloid-beta Fibril Formation. IMPLICATIONS FOR THE MECHANISM OF PATHOGENESIS IN ALZHEIMER'S DISEASE Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers Alpha1-antichymotrypsin/Alzheimer's peptide Abeta(1-42) complex perturbs lipid metabolism and activates transcription factors PPARgamma and NFkappaB in human neuroblastoma (Kelly) cells Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio Effect of N-homocysteinylation on physicochemical and cytotoxic properties of amyloid β-peptide Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins Amyloid-beta neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity Pathways towards and away from Alzheimer's disease Immunization with the SDPM1 peptide lowers amyloid plaque burden and improves cognitive function in the APPswePSEN1(A246E) transgenic mouse model of Alzheimer's disease.Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease MyD88 deficiency ameliorates β-amyloidosis in an animal model of Alzheimer's disease Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases Reelin signaling antagonizes beta-amyloid at the synapse Simulating oligomerization at experimental concentrations and long timescales: A Markov state model approach Amyloids: friend or foe?Stabilization of neurotoxic soluble beta-sheet-rich conformations of the Alzheimer's disease amyloid-beta peptide Signaling effect of amyloid-beta(42) on the processing of AbetaPP Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease Synaptic plasticity in animal models of early Alzheimer's disease Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease Novel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease.Synapses and Alzheimer's disease Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer's disease Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease The Rationale for Insulin Therapy in Alzheimer's Disease The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy Amyloid-β-Induced Dysregulation of AMPA Receptor Trafficking Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

http://www.wikidata.org/entity/Q29547593

description

1998 nî lūn-bûn

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1998 թուականի Մայիսին հրատարակուած գիտական յօդուած

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1998 թվականի մայիսին հրատարակված գիտական հոդված

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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name

Diffusible, nonfibrillar ligan ...... ral nervous system neurotoxins

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Diffusible, nonfibrillar ligan ...... ral nervous system neurotoxins

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type

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Diffusible, nonfibrillar ligan ...... ral nervous system neurotoxins

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Diffusible, nonfibrillar ligan ...... ral nervous system neurotoxins

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Diffusible, nonfibrillar ligan ...... ral nervous system neurotoxins

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Diffusible, nonfibrillar ligan ...... ral nervous system neurotoxins

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PNAS.95.11.6448

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Proceedings of the National Academy of Sciences of the United States of America

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Diffusible, nonfibrillar ligan ...... ral nervous system neurotoxins

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Barlow AK

http://www.w3.org/2001/XMLSchema#string

Chromy BA

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Edwards C

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Finch CE

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Freed R

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Klein WL

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Krafft GA

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Lambert MP

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Liosatos M

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Morgan TE

http://www.w3.org/2001/XMLSchema#string

P2860

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice

Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment

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6448-53

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scholarly article

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131277

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11

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95

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1998-05-26T00:00:00Z

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13683178

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9600986

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27787

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