Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
about
Transthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid.Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study.New Class of Inhibitors of Amyloid-beta Fibril Formation. IMPLICATIONS FOR THE MECHANISM OF PATHOGENESIS IN ALZHEIMER'S DISEASECellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomersAlpha1-antichymotrypsin/Alzheimer's peptide Abeta(1-42) complex perturbs lipid metabolism and activates transcription factors PPARgamma and NFkappaB in human neuroblastoma (Kelly) cellsNeurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratioEffect of N-homocysteinylation on physicochemical and cytotoxic properties of amyloid β-peptideApolipoprotein J (clusterin) activates rodent microglia in vivo and in vitroProgressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteinsAmyloid-beta neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activityPathways towards and away from Alzheimer's diseaseImmunization with the SDPM1 peptide lowers amyloid plaque burden and improves cognitive function in the APPswePSEN1(A246E) transgenic mouse model of Alzheimer's disease.Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's diseaseMyD88 deficiency ameliorates β-amyloidosis in an animal model of Alzheimer's diseaseSynthetic amyloid-beta oligomers impair long-term memory independently of cellular prion proteinKnockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal NeurogenesisAmyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memorySoluble oligomers of the amyloid beta-protein impair synaptic plasticity and behaviorLipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in miceProtein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseasesReelin signaling antagonizes beta-amyloid at the synapseSimulating oligomerization at experimental concentrations and long timescales: A Markov state model approachAmyloids: friend or foe?Stabilization of neurotoxic soluble beta-sheet-rich conformations of the Alzheimer's disease amyloid-beta peptideSignaling effect of amyloid-beta(42) on the processing of AbetaPPFenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's diseaseSoluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptakeSoluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's diseaseSynaptic plasticity in animal models of early Alzheimer's diseaseLoss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer diseaseInflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's diseaseNovel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease.Synapses and Alzheimer's diseaseNeurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer's diseaseMulti-Target Directed Donepezil-Like Ligands for Alzheimer's DiseaseThe Rationale for Insulin Therapy in Alzheimer's DiseaseThe Role of Amyloid-β Oligomers in Toxicity, Propagation, and ImmunotherapyAmyloid-β-Induced Dysregulation of AMPA Receptor TraffickingOverview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds
P2860
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P2860
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
description
1998 nî lūn-bûn
@nan
1998 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Diffusible, nonfibrillar ligan ...... ral nervous system neurotoxins
@ast
Diffusible, nonfibrillar ligan ...... ral nervous system neurotoxins
@en
type
label
Diffusible, nonfibrillar ligan ...... ral nervous system neurotoxins
@ast
Diffusible, nonfibrillar ligan ...... ral nervous system neurotoxins
@en
prefLabel
Diffusible, nonfibrillar ligan ...... ral nervous system neurotoxins
@ast
Diffusible, nonfibrillar ligan ...... ral nervous system neurotoxins
@en
P2093
P2860
P3181
P356
P1476
Diffusible, nonfibrillar ligan ...... ral nervous system neurotoxins
@en
P2093
Lambert MP
Liosatos M
P2860
P304
P3181
P356
10.1073/PNAS.95.11.6448
P407
P577
1998-05-26T00:00:00Z