Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia - Test2 - elhamkhani - TriplyDB

Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia

Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia

http://www.wikidata.org/entity/Q29616211

about

EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor Overexpressed BCL6 (LAZ3) oncoprotein triggers apoptosis, delays S phase progression and associates with replication foci Sequestration and inhibition of Daxx-mediated transcriptional repression by PML A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness BCoR, a novel corepressor involved in BCL-6 repression Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1 The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex.A novel cervical cancer suppressor 3 (CCS-3) interacts with the BTB domain of PLZF and inhibits the cell growth by inducing apoptosis Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4.The methyl-CpG binding protein MBD1 is required for PML-RARalpha function.ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome The estrogen-responsive B box protein is a novel regulator of the retinoid signal ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor Cloning and characterization of a novel human histone deacetylase, HDAC8 UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation.Nuclear receptor corepressors Arsenic trioxide is a potent inhibitor of the interaction of SMRT corepressor with Its transcription factor partners, including the PML-retinoic acid receptor alpha oncoprotein found in human acute promyelocytic leukemia Oligomerization of ETO is obligatory for corepressor interaction The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain.Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching A histone deacetylase corepressor complex regulates the Notch signal transduction pathway Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway Isolation from cochlea of a novel human intronless gene with predominant fetal expression ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex The transcription factor PLZF directs the effector program of the NKT cell lineage Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZ Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF PLZF is a negative regulator of retinoic acid receptor transcriptional activity Unique forms of human and mouse nuclear receptor corepressor SMRT

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Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia

http://www.wikidata.org/entity/Q29616211

description

1998 nî lūn-bûn

@nan

1998 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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name

Fusion proteins of the retinoi ...... ase in promyelocytic leukaemia

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Fusion proteins of the retinoi ...... ase in promyelocytic leukaemia

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type

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Fusion proteins of the retinoi ...... ase in promyelocytic leukaemia

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Fusion proteins of the retinoi ...... ase in promyelocytic leukaemia

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Fusion proteins of the retinoi ...... ase in promyelocytic leukaemia

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Fusion proteins of the retinoi ...... ase in promyelocytic leukaemia

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F F Ferrara

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F Grignani

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I Zamir

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L Tomassoni

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10.1038/35901

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