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Membrane transporters in drug development

Membrane transporters in drug development

http://www.wikidata.org/entity/Q29616802

about

How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1 Cobicistat boosts the intestinal absorption of transport substrates, including HIV protease inhibitors and GS-7340, in vitro Mechanisms of drug resistance in colon cancer and its therapeutic strategies Fitting Transporter Activities to Cellular Drug Concentrations and Fluxes: Why the Bumblebee Can Fly Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics Cell-culture models of the blood-brain barrier Clinical pharmacokinetics and pharmacodynamics of the endothelin receptor antagonist macitentan Optimized approaches for quantification of drug transporters in tissues and cells by MRM proteomics Non-systemic drugs: a critical review Cholinergic modulation by opioid receptor ligands: potential application to Alzheimer's disease The role of transporters in toxicity and disease Importance of multi-p450 inhibition in drug-drug interactions: evaluation of incidence, inhibition magnitude, and prediction from in vitro data SLC transporters as therapeutic targets: emerging opportunities ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans Persistent pharmacokinetic challenges to pediatric drug development Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery pH Dependent but not P-gp Dependent Bidirectional Transport Study of S-propranolol: The Importance of Passive Diffusion Active sulforhodamine 101 uptake into hippocampal astrocytes Crystal structure of a eukaryotic phosphate transporter Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters Selectivity profiling of BCRP versus P-gp inhibition: from automated collection of polypharmacology data to multi-label learning Metrabase: a cheminformatics and bioinformatics database for small molecule transporter data analysis and (Q)SAR modeling Annotating Human P-Glycoprotein Bioassay Data Renal drug transporters and their significance in drug-drug interactions Recent advances in understanding hepatic drug transport Drug transporters in tissues and cells relevant to sexual transmission of HIV: Implications for drug delivery The organic anion transporter (OAT) family: a systems biology perspective Pharmacokinetic interactions of herbs with cytochrome p450 and p-glycoprotein Inhibition of OATP-1B1 and OATP-1B3 by tyrosine kinase inhibitors DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma P-Glycoprotein Transport of Neurotoxic Pesticides Regulatory pathways for ATP-binding cassette transport proteins in kidney proximal tubules Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition Predicting P-glycoprotein-mediated drug transport based on support vector machine and three-dimensional crystal structure of P-glycoprotein Sensitive and specific fluorescent probes for functional analysis of the three major types of mammalian ABC transporters Organic anion and cation SLC22 "drug" transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule Gene expression variability in human hepatic drug metabolizing enzymes and transporters A method to measure hydrolytic activity of adenosinetriphosphatases (ATPases)Bioengineered 3D human kidney tissue, a platform for the determination of nephrotoxicity

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P2860

Membrane transporters in drug development

http://www.wikidata.org/entity/Q29616802

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Membrane transporters in drug development

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Nature Reviews Drug Discovery

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Membrane transporters in drug development

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Amber Dahlin

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Caroline A Lee

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Dietrich Keppler

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Donald J Tweedie

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International Transporter Consortium

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Joseph A Ware

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Kathleen M Giacomini

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Kathleen M Hillgren

http://www.w3.org/2001/XMLSchema#string

Keith A Hoffmaster

http://www.w3.org/2001/XMLSchema#string

Lei Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

A multidrug resistance transporter from human MCF-7 breast cancer cells

Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1

Reduction of metformin renal tubular secretion by cimetidine in man

Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia

A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters

A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane

Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics

The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction

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215-236

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910042

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10.1038/NRD3028

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1049513504

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20190787

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3326076

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