The ErbB signaling network: receptor heterodimerization in development and cancer
about
Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophreniaAnalysis of transient phosphorylation-dependent protein-protein interactions in living mammalian cells using split-TEVAn RBCC protein implicated in maintenance of steady-state neuregulin receptor levelsErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent mannerEpidermal growth factor directs sex-specific steroid signaling through Src activationIdentification of a region within the ErbB2/HER2 intracellular domain that is necessary for ligand-independent associationMechanism of activation and inhibition of the HER4/ErbB4 kinaseADP-ribosylation factor 4 small GTPase mediates epidermal growth factor receptor-dependent phospholipase D2 activationHeregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcriptionProtein phosphorylation profiling using an in situ proximity ligation assay: phosphorylation of AURKA-elicited EGFR-Thr654 and EGFR-Ser1046 in lung cancer cellsPI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancerN-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration.The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand.Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4.Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2Identification of novel ErbB3-interacting factors using the split-ubiquitin membrane yeast two-hybrid systemNedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cellsQuercetin-induced ubiquitination and down-regulation of Her-2/neuA comprehensive pathway map of epidermal growth factor receptor signalingPhosphotyrosine interactome of the ErbB-receptor kinase familyPlexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferationNeuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1Neuregulin3 alters cell fate in the epidermis and mammary glandDifferential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skinBAD: a good therapeutic target?Essential function for ErbB3 in breast cancer proliferationTrastuzumab, an appropriate first-line single-agent therapy for HER2-overexpressing metastatic breast cancerThe glial growth factors deficiency and synaptic destabilization hypothesis of schizophreniaThe importance of being a myoepithelial cell.Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutantsChanges in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice.Differential responses to doxorubicin-induced phosphorylation and activation of Akt in human breast cancer cells.Phase I clinical study of the recombinant antibody toxin scFv(FRP5)-ETA specific for the ErbB2/HER2 receptor in patients with advanced solid malignomasFunctional interaction between mouse erbB3 and wild-type rat c-neu in transgenic mouse mammary tumor cells.Soluble Epidermal Growth Factor Receptors (sEGFRs) in Cancer: Biological Aspects and Clinical RelevanceChanging strategies for target therapy in gastric cancerInsulin-like growth factor and epidermal growth factor signaling in breast cancer cell growth: focus on endocrine resistant diseaseEGFR/HER-targeted therapeutics in ovarian cancerTargeting of erbB3 receptor to overcome resistance in cancer treatment
P2860
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P2860
The ErbB signaling network: receptor heterodimerization in development and cancer
description
2000 nî lūn-bûn
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2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
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2000 թվականի հուլիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
The ErbB signaling network: receptor heterodimerization in development and cancer
@ast
The ErbB signaling network: receptor heterodimerization in development and cancer
@en
type
label
The ErbB signaling network: receptor heterodimerization in development and cancer
@ast
The ErbB signaling network: receptor heterodimerization in development and cancer
@en
prefLabel
The ErbB signaling network: receptor heterodimerization in development and cancer
@ast
The ErbB signaling network: receptor heterodimerization in development and cancer
@en
P2093
P2860
P3181
P356
P1433
P1476
The ErbB signaling network: receptor heterodimerization in development and cancer
@en
P2093
P2860
P304
P3181
P356
10.1093/EMBOJ/19.13.3159
P407
P577
2000-07-03T00:00:00Z