Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
about
FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapiesSmall molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signallingVRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancerConserved oncogenic behavior of the FAM83 family regulates MAPK signaling in human cancerOncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signalingGenetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cellsRanBPM is an inhibitor of ERK signalingProline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activationHyperactivation of EGFR and downstream effector phospholipase D1 by oncogenic FAM83BRaf family kinases: old dogs have learned new tricksPME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant gliomaComplexity in KSR function revealed by Raf inhibitor and KSR structure studiescPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatisThe mTOR signalling pathway in human cancerStructure-activity-dependent regulation of cell communication by perfluorinated fatty acids using in vivo and in vitro model systemsSelectivity of docking sites in MAPK kinasesIQGAPs in cancer: a family of scaffold proteins underlying tumorigenesisExpression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomasImmunobiology of hepatocarcinogenesis: Ways to go or almost there?MLK3 Signaling in Cancer InvasionMolecular Subtypes and Personalized Therapy in Metastatic Colorectal CancerThe value of genomics in dissecting the RAS-network and in guiding therapeutics for RAS-driven cancersMicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemiaHsp90 Inhibitors for the Treatment of Chronic Myeloid LeukemiaBRAF mutant colorectal cancer as a distinct subset of colorectal cancer: clinical characteristics, clinical behavior, and response to targeted therapiesc-Met as a Target for Personalized TherapyMolecular Targeting of ERKs/RSK2 Signaling Axis in Cancer PreventionGenomically driven precision medicine to improve outcomes in anaplastic thyroid cancerPrinciples of allosteric interactions in cell signalingAllosteric activation transitions in enzymes and biomolecular motors: insights from atomistic and coarse-grained simulationsA quantitative comparison of human HT-1080 fibrosarcoma cells and primary human dermal fibroblasts identifies a 3D migration mechanism with properties unique to the transformed phenotypeExpression of B-RAF V600E in type II pneumocytes causes abnormalities in alveolar formation, airspace enlargement and tumor formation in miceNovel Reporter for Faithful Monitoring of ERK2 Dynamics in Living Cells and Model Organisms.Chemotherapeutic Potential of 2-[Piperidinoethoxyphenyl]-3-Phenyl-2H-Benzo(b)pyran in Estrogen Receptor- Negative Breast Cancer Cells: Action via Prevention of EGFR Activation and Combined Inhibition of PI-3-K/Akt/FOXO and MEK/Erk/AP-1 PathwaysNovel allosteric sites on Ras for lead generationDual pharmacological targeting of the MAP kinase and PI3K/mTOR pathway in preclinical models of colorectal cancerSchwann cells induce cancer cell dispersion and invasion.Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumorsAllosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF KinaseRAC1P29S is a spontaneously activating cancer-associated GTPase
P2860
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P2860
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
description
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im Mai 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 14 May 2007)
@en
wetenschappelijk artikel (gepubliceerd op 2007/05/14)
@nl
наукова стаття, опублікована в травні 2007
@uk
مقالة علمية (نشرت في 14-5-2007)
@ar
name
Targeting the Raf-MEK-ERK mito ...... de for the treatment of cancer
@ast
Targeting the Raf-MEK-ERK mito ...... de for the treatment of cancer
@en
type
label
Targeting the Raf-MEK-ERK mito ...... de for the treatment of cancer
@ast
Targeting the Raf-MEK-ERK mito ...... de for the treatment of cancer
@en
prefLabel
Targeting the Raf-MEK-ERK mito ...... de for the treatment of cancer
@ast
Targeting the Raf-MEK-ERK mito ...... de for the treatment of cancer
@en
P2860
P3181
P356
P1433
P1476
Targeting the Raf-MEK-ERK mito ...... de for the treatment of cancer
@en
P2093
P2860
P2888
P304
P3181
P356
10.1038/SJ.ONC.1210422
P407
P577
2007-05-14T00:00:00Z
P5875
P6179
1013706518