Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity
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Mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residuesRefinement and prediction of protein prenylation motifsStructure of Protein Geranylgeranyltransferase-I from the Human Pathogen Candida albicans Complexed with a Lipid SubstrateCaged Protein Prenyltransferase Substrates: Tools for Understanding Protein PrenylationStructural Basis for Binding and Selectivity of Antimalarial and Anticancer Ethylenediamine Inhibitors to Protein FarnesyltransferaseStructures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal PathogensCrystal structures of the fungal pathogenAspergillus fumigatusprotein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug designGeranylgeranyl diphosphate synthase: an emerging therapeutic targetThematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylationAberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanismsIdentification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI bindingTargeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancerExpansion of protein farnesyltransferase specificity using "tunable" active site interactions: development of bioengineered prenylation pathways.Identification of a novel class of farnesylation targets by structure-based modeling of binding specificity.Reversible inactivation of the transcriptional function of P53 protein by farnesylation.Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase.Evaluation of protein farnesyltransferase substrate specificity using synthetic peptide libraries.Identification of novel peptide substrates for protein farnesyltransferase reveals two substrate classes with distinct sequence selectivities.Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substratesPurification of the CaaX-modified, dynamin-related large GTPase hGBP1 by coexpression with farnesyltransferaseMeasurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitorsTargeting protein prenylation for cancer therapySpectroscopic and mechanistic studies of heterodimetallic forms of metallo-β-lactamase NDM-1.Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes.A novel approach to tag and identify geranylgeranylated proteins.Prediction and evaluation of protein farnesyltransferase inhibition by commercial drugs.An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria.Chlamydial IFN-gamma immune evasion is linked to host infection tropism.Therapeutic intervention based on protein prenylation and associated modificationsRapid analysis of protein farnesyltransferase substrate specificity using peptide libraries and isoprenoid diphosphate analogues.Combinatorial modulation of protein prenylationRal small GTPase signaling and oncogenesis: More than just 15minutes of fameFarnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferaseLipid posttranslational modifications. Farnesyl transferase inhibitors.The RalGEF-Ral Effector Signaling Network: The Road Less Traveled for Anti-Ras Drug Discovery.Isoprenoids and related pharmacological interventions: potential application in Alzheimer's disease.GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer.An enzyme-coupled continuous fluorescence assay for farnesyl diphosphate synthasesDivergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases.Exploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs.
P2860
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P2860
Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity
description
2004 nî lūn-bûn
@nan
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Crystallographic analysis of C ...... protein substrate selectivity
@ast
Crystallographic analysis of C ...... protein substrate selectivity
@en
Crystallographic analysis of C ...... protein substrate selectivity
@en-gb
Crystallographic analysis of C ...... protein substrate selectivity
@nl
type
label
Crystallographic analysis of C ...... protein substrate selectivity
@ast
Crystallographic analysis of C ...... protein substrate selectivity
@en
Crystallographic analysis of C ...... protein substrate selectivity
@en-gb
Crystallographic analysis of C ...... protein substrate selectivity
@nl
prefLabel
Crystallographic analysis of C ...... protein substrate selectivity
@ast
Crystallographic analysis of C ...... protein substrate selectivity
@en
Crystallographic analysis of C ...... protein substrate selectivity
@en-gb
Crystallographic analysis of C ...... protein substrate selectivity
@nl
P2093
P1476
Crystallographic analysis of C ...... protein substrate selectivity
@en
P2093
Kimberly L Terry
Lorena S Beese
Patrick J Casey
T Scott Reid
P304
P356
10.1016/J.JMB.2004.08.056
P407
P577
2004-10-15T00:00:00Z