Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection - Test2 - elhamkhani - TriplyDB

Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection

Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection

http://www.wikidata.org/entity/Q29620702

about

NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling Nonstructural protein 5A of hepatitis C virus inhibits the function of karyopherin beta3 Hepatitis C genotype 6: A concise review and response-guided therapy proposal Hepatitis C virus protease inhibitor-resistance mutations: our experience and review Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action Replicative homeostasis: a fundamental mechanism mediating selective viral replication and escape mutation Factors associated with the response to interferon-based antiviral therapies for chronic hepatitis C Hepatitis C virus molecular evolution: transmission, disease progression and antiviral therapy Viral quasispecies evolution Production of infectious HCV genotype 1b virus in cell culture using a novel Set of adaptive mutations Prospective characterization of full-length hepatitis C virus NS5A quasispecies during induction and combination antiviral therapy Clinical relevance of hepatitis C virus genotypes.Effect of retreatment with interferon alone or interferon plus ribavirin on hepatitis C virus quasispecies diversification in nonresponder patients with chronic hepatitis C.Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation.Evolution of hepatitis C virus quasispecies in hypervariable region 1 and the putative interferon sensitivity-determining region during interferon therapy and natural infection.Interferon resistance of hepatitis C virus genotype 1b: relationship to nonstructural 5A gene quasispecies mutations The NS5A/NS5 proteins of viruses from three genera of the family flaviviridae are phosphorylated by associated serine/threonine kinases Genetic heterogeneity of hypervariable region 1 of the hepatitis C virus (HCV) genome and sensitivity of HCV to alpha interferon therapy.Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesis Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase Hyperphosphorylation of the hepatitis C virus NS5A protein requires an active NS3 protease, NS4A, NS4B, and NS5A encoded on the same polyprotein Mutations in Hepatitis C Virus RNAs Conferring Cell Culture Adaptation Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations.Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response.Regulation of mRNA Translation and Cellular Signaling by Hepatitis C Virus Nonstructural Protein NS5A Effect of alpha interferon on the hepatitis C virus replicon Early changes in hepatitis C viral quasispecies during interferon therapy predict the therapeutic outcome Regulation of PKR and IRF-1 during hepatitis C virus RNA replication.Comparative sequence analysis of the core protein and its frameshift product, the F protein, of hepatitis C virus subtype 1b strains obtained from patients with and without hepatocellular carcinoma.Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cells.Persistent and transient replication of full-length hepatitis C virus genomes in cell culture Subversion of Cell Signaling Pathways by Hepatitis C Virus Nonstructural 5A Protein via Interaction with Grb2 and P85 Phosphatidylinositol 3-Kinase Hepatitis C virus nonstructural 5A protein and interferon resistance: a new model for testing the reliability of mutational analyses.PKR-dependent mechanisms of gene expression from a subgenomic hepatitis C virus clone.Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees.Hepatitis C Virus NS3 ATPases/Helicases from Different Genotypes Exhibit Variations in Enzymatic Properties Protein-Protein Interactions between Hepatitis C Virus Nonstructural Proteins Amphipathic Helix-Dependent Localization of NS5A Mediates Hepatitis C Virus RNA Replication Gene Expression Profiling of the Cellular Transcriptional Network Regulated by Alpha/Beta Interferon and Its Partial Attenuation by the Hepatitis C Virus Nonstructural 5A Protein Evidence of recombination in quasispecies populations of a Hepatitis C Virus patient undergoing anti-viral therapy

P2860

Q22009551-3EECDDF2-ABC9-4C49-BCDE-51CD4F20FD28 Q22254038-63D94C14-5B47-45E6-8A24-200114D68B8D Q22305417-F6EC8609-F2A6-409B-B03B-7208CEBB156E Q24628717-E3ECA893-05DD-4E41-ACB2-35EB17191513 Q24672548-0CCD5698-A80B-4416-A6AA-17AE553C36A6 Q24798257-43DD50E7-64D4-4D1E-8B04-B1FA4B573D26 Q26825715-CA9F17B8-CB7C-457F-9F05-52760BD78064 Q26853500-3E1D2F7B-A9F7-4361-B528-2DA1A3EF892A Q27013917-C060056D-2A7A-499A-A8F5-1893BA0191B9 Q27468653-AC91E37B-BFA7-46F2-95DB-343E3BC5CA0E Q27469310-30EB4E3A-25D8-447D-95B5-83CBAA5AD832 Q27469323-C641F561-15D6-444B-A80E-A6ECE35BCBDB Q27469364-1AFD05FA-1DC9-44E8-8D53-64AECB0012EB Q27469500-A3B85C94-0BC0-44B8-8697-7722D6E2024A Q27469549-80B241E4-7CD4-46CA-88DE-632CCD427F52 Q27469554-6C0B6E10-D608-4F9D-BFE7-730B33499B68 Q27469584-6C70366D-67B9-4177-8E03-25579C7C8330 Q27469620-F900A631-0B26-408B-B3B2-EBC18E11E6E3 Q27469667-3488AF28-16FA-42D4-A481-AD5BDCE4EA68 Q27469720-D83505B9-3F36-4591-B5DD-A984C8667383 Q27469751-C45918F7-F622-4898-8AEA-AA5BC8223726 Q27469769-F16EFD77-E652-4508-BF54-4842B838DAC5 Q27469794-B16CD925-C19D-42FC-8BE3-C556072A9345 Q27469808-BE0FDF80-9D95-4B7A-BEFE-9011369BEF47 Q27469918-9C52C348-DFF8-42FC-974D-26D592F59543 Q27469963-7C817104-5CD9-401E-B91B-EF2FDEE4A10C Q27471683-FA967CF4-5A5C-4328-8402-A17D8DFAC0F2 Q27472373-115BE8F0-3DA5-41E2-9154-7AE1006EDB25 Q27472753-B9AF8AF1-2B46-47E5-AF11-EC355F517342 Q27472846-F26DF4E1-55BD-4746-ACF9-A92F3490C389 Q27472869-B3B1A1AA-CC94-452F-AAB1-063685E8EDE6 Q27472897-FA9C27D6-931B-4A7C-9C11-76D4FE754AED Q27472905-3ECEFF1F-D982-4FEB-9B5C-9BCD94D6DD31 Q27472907-C98BF8B2-916D-4109-B432-6584085DB2B3 Q27473004-0AE21B9F-BA6A-4B49-AB92-5AC57BDE2892 Q27473372-5D6028C3-6451-4CF0-9961-C35444E660C8 Q27473469-2301CBFF-D466-4E17-B7F2-0478F13EFA06 Q27473477-2F6DE8CB-112C-4FF6-AD6B-A3B9880EEF6F Q27473508-E42FBCF9-5944-485E-90A5-95599B126C5E Q27477594-5BE4B0F1-16BC-46D5-8A2D-8AFD158D5423

P2860

Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection

http://www.wikidata.org/entity/Q29620702

description

1996 nî lūn-bûn

@nan

1996 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

1996 թվականի հունվարին հրատարակված գիտական հոդված

@hy

1996年の論文

@ja

1996年論文

@yue

1996年論文

@zh-hant

1996年論文

@zh-hk

1996年論文

@zh-mo

1996年論文

@zh-tw

1996年论文

@wuu

name

Mutations in the nonstructural ...... hepatitis C virus 1b infection

@ast

Mutations in the nonstructural ...... hepatitis C virus 1b infection

@en

type

label

Mutations in the nonstructural ...... hepatitis C virus 1b infection

@ast

Mutations in the nonstructural ...... hepatitis C virus 1b infection

@en

prefLabel

Mutations in the nonstructural ...... hepatitis C virus 1b infection

@ast

Mutations in the nonstructural ...... hepatitis C virus 1b infection

@en

P1433

Q29620702-645EC00F-6353-4A63-A641-52FD1BE68210

P1476

Q29620702-0551F669-5914-441A-970F-3E755F02527B

P2093

Q29620702-161B720A-56E8-40F2-84D1-2FF11B401E2C

Q29620702-1F29FF50-10F2-4726-B56E-081939A6054C

Q29620702-4337836C-A726-4017-922A-F17C15A3CBB4

Q29620702-8BBDBD35-3897-4EA2-9160-825E015568FC

Q29620702-B01D16C0-DB4F-45DD-AE85-818B2CC0F253

Q29620702-C380294C-E344-4D2F-97DB-B05E7E12FC56

Q29620702-CFF236F1-736C-4537-A723-FB4FDA490DB9

Q29620702-D975727D-92D3-4E2F-8246-507EEA0980F6

Q29620702-EAF3726A-7B44-4300-BB5F-14855B2F0042

Q29620702-FC5FEC76-AC1F-4798-8076-CB437E8A997E

P304

Q29620702-95780A72-FAE0-4F58-A0C1-5B1E44CDEDF1

P31

Q29620702-5F57F29A-6812-4985-B440-C4CBBCDE6BA3

P3181

Q29620702-6194E731-D696-4B8D-BCAD-6379CF64E406

P356

Q29620702-F7C5C47A-1257-46B7-BE04-6576C8B3A02D

P407

Q29620702-9927EDFD-0CDE-4884-941A-4AC96D3ABAB3

P433

Q29620702-66631A9D-C00F-4551-93FE-1E4D03DA08D7

P478

Q29620702-C12F3AE5-633C-4CBC-932D-2A31B60D8696

P577

Q29620702-C6EF3F27-8D4C-42FE-B8A4-364AA7331244

P698

Q29620702-6860D399-3258-4316-B50C-5D2118D40D20

P921

Q29620702-19BA6660-C6EA-4C5B-91ED-FDB05275D141

P3181

P356

NEJM199601113340203

P1433

The New England Journal of Medicine

P1476

Mutations in the nonstructural ...... hepatitis C virus 1b infection

@en

P2093

Asahina Y

http://www.w3.org/2001/XMLSchema#string

Enomoto N

http://www.w3.org/2001/XMLSchema#string

Izumi N

http://www.w3.org/2001/XMLSchema#string

Kurosaki M

http://www.w3.org/2001/XMLSchema#string

Marumo F

http://www.w3.org/2001/XMLSchema#string

Murakami T

http://www.w3.org/2001/XMLSchema#string

Ogura Y

http://www.w3.org/2001/XMLSchema#string

Sakuma I

http://www.w3.org/2001/XMLSchema#string

Sato C

http://www.w3.org/2001/XMLSchema#string

Yamamoto C

http://www.w3.org/2001/XMLSchema#string

P304

77-81

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

3321187

http://www.w3.org/2001/XMLSchema#string

P356

10.1056/NEJM199601113340203

http://www.w3.org/2001/XMLSchema#string

P407

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

334

http://www.w3.org/2001/XMLSchema#string

P577

1996-01-11T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

8531962

http://www.w3.org/2001/XMLSchema#string

P921