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Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distributionThe association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohortsTwelve type 2 diabetes susceptibility loci identified through large-scale association analysisGenome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetesVariants in MTNR1B influence fasting glucose levels.Six new loci associated with body mass index highlight a neuronal influence on body weight regulationCommon missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrationsIncreased Melatonin Signaling Is a Risk Factor for Type 2 DiabetesPolymorphisms in the gene encoding the voltage-dependent Ca(2+) channel Ca (V)2.3 (CACNA1E) are associated with type 2 diabetes and impaired insulin secretionNew genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes riskLarge-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetesIdentification of ten loci associated with height highlights new biological pathways in human growthA genome-wide association search for type 2 diabetes genes in African AmericansGenetic variation in ATP5O is associated with skeletal muscle ATP50 mRNA expression and glucose uptake in young twinsGenome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibilityMeta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.Association analyses of 249,796 individuals reveal 18 new loci associated with body mass indexGenome-wide association analysis identifies loci for type 2 diabetes and triglyceride levelsThe genetic architecture of type 2 diabetesA central role for GRB10 in regulation of islet function in man.Variation in GYS1 interacts with exercise and gender to predict cardiovascular mortality.Stressful life events and the metabolic syndrome: the prevalence, prediction and prevention of diabetes (PPP)-Botnia Study.GAD antibody positivity predicts type 2 diabetes in an adult population.Loss-of-function mutations in SLC30A8 protect against type 2 diabetesDetailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.Latent autoimmune diabetes in adults differs genetically from classical type 1 diabetes diagnosed after the age of 35 years.Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distributionNovel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.Comprehensive association testing of common mitochondrial DNA variation in metabolic disease.Genome wide meta-analysis highlights the role of genetic variation in RARRES2 in the regulation of circulating serum chemerin.Two common genetic variants near nuclear-encoded OXPHOS genes are associated with insulin secretion in vivo.Clinical risk factors, DNA variants, and the development of type 2 diabetes.Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretionIdentification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies.Pleiotropic effects of GIP on islet function involve osteopontin.Depressive symptoms, antidepressant medication use, and insulin resistance: the PPP-Botnia StudyGenetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profileNo interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.
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