LGN blocks the ability of NuMA to bind and stabilize microtubules. A mechanism for mitotic spindle assembly regulation.
about
Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell divisionGalphai generates multiple Pins activation states to link cortical polarity and spindle orientation in Drosophila neuroblastsSubcellular localization of LGN during mitosis: evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progressionDynein/dynactin regulate metaphase spindle length by targeting depolymerizing activities to spindle poles.Epithelial homeostasisLGN/mInsc and LGN/NuMA Complex Structures Suggest Distinct Functions in Asymmetric Cell Division for the Par3/mInsc/LGN and Gαi/LGN/NuMA PathwaysCrystal structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from GαiComprehensive analysis of LANA interacting proteins essential for viral genome tethering and persistenceNuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures.NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein functionNuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.Nuclear Mitotic Apparatus (NuMA) Interacts with and Regulates Astrin at the Mitotic SpindleCell cycle-regulated membrane binding of NuMA contributes to efficient anaphase chromosome separation.LGN regulates mitotic spindle orientation during epithelial morphogenesis.Kaposi's sarcoma-associated herpesvirus-encoded LANA can interact with the nuclear mitotic apparatus protein to regulate genome maintenance and segregation.ABL1 regulates spindle orientation in adherent cells and mammalian skin.Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension.Evidence for dynein and astral microtubule-mediated cortical release and transport of Gαi/LGN/NuMA complex in mitotic cellsNuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions.Force on spindle microtubule minus ends moves chromosomesXenopus importin beta validates human importin beta as a cell cycle negative regulatorNuMA after 30 years: the matrix revisited.Resistance to inhibitors of cholinesterase 8A catalyzes release of Galphai-GTP and nuclear mitotic apparatus protein (NuMA) from NuMA/LGN/Galphai-GDP complexes.Regulation of the AGS3·G{alpha}i signaling complex by a seven-transmembrane span receptor.KSHV LANA--the master regulator of KSHV latency.Importin alpha/beta and Ran-GTP regulate XCTK2 microtubule binding through a bipartite nuclear localization signal.A lateral belt of cortical LGN and NuMA guides mitotic spindle movements and planar division in neuroepithelial cellsMolecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesisMTCL1 crosslinks and stabilizes non-centrosomal microtubules on the Golgi membrane.Regulation of NDR1 activity by PLK1 ensures proper spindle orientation in mitosisMechanistic pathways and biological roles for receptor-independent activators of G-protein signaling.G-protein signaling: back to the futureCell cycle-regulated cortical dynein/dynactin promotes symmetric cell division by differential pole motion in anaphase.Scaffolding proteins in G-protein signalingAsymmetric cell divisions in the epidermis.Dynamic localization of LIN-5 and GPR-1/2 to cortical force generation domains during spindle positioning.Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.The classical nuclear localization signal receptor, importin-alpha, is required for efficient transition through the G1/S stage of the cell cycle in Saccharomyces cerevisiae.Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cellsTransportin regulates major mitotic assembly events: from spindle to nuclear pore assembly.
P2860
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P2860
LGN blocks the ability of NuMA to bind and stabilize microtubules. A mechanism for mitotic spindle assembly regulation.
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
LGN blocks the ability of NuMA ...... c spindle assembly regulation.
@ast
LGN blocks the ability of NuMA ...... c spindle assembly regulation.
@en
type
label
LGN blocks the ability of NuMA ...... c spindle assembly regulation.
@ast
LGN blocks the ability of NuMA ...... c spindle assembly regulation.
@en
prefLabel
LGN blocks the ability of NuMA ...... c spindle assembly regulation.
@ast
LGN blocks the ability of NuMA ...... c spindle assembly regulation.
@en
P1433
P1476
LGN blocks the ability of NuMA ...... c spindle assembly regulation.
@en
P2093
Ian G Macara
Laura Taylor
P304
P356
10.1016/S0960-9822(02)01298-8
P407
P577
2002-11-01T00:00:00Z