Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity. - Test2 - elhamkhani - TriplyDB

Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.

Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.

http://www.wikidata.org/entity/Q36739939

about

Regulation of localization and activity of the microtubule depolymerase MCAK Aurora A's Functions During Mitotic Exit: The Guess Who Game Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle Regulatory mechanisms that control mitotic kinesins The KLP-7 Residue S546 Is a Putative Aurora Kinase Site Required for Microtubule Regulation at the Centrosome in C. elegans The far C-terminus of MCAK regulates its conformation and spindle pole focusing.KLP-7 acts through the Ndc80 complex to limit pole number in C. elegans oocyte meiotic spindle assembly.Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2 MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics.Lamin B counteracts the kinesin Eg5 to restrain spindle pole separation during spindle assembly Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1).Aurora A kinase and its substrate TACC3 are required for central spindle assembly Aurora B inhibits MCAK activity through a phosphoconformational switch that reduces microtubule association Rac1 and Aurora A regulate MCAK to polarize microtubule growth in migrating endothelial cells.Spatiotemporal dynamics of Aurora B-PLK1-MCAK signaling axis orchestrates kinetochore bi-orientation and faithful chromosome segregation.MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes.MCAK-mediated regulation of endothelial cell microtubule dynamics is mechanosensitive to myosin-II contractility.Aurora A orchestrates entosis by regulating a dynamic MCAK-TIP150 interaction How kinesin motor proteins drive mitotic spindle function: Lessons from molecular assays.Aurora A contributes to p150(glued) phosphorylation and function during mitosis The elegans of spindle assembly.PLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activity Nup98 regulates bipolar spindle assembly through association with microtubules and opposition of MCAK.Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics.Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target.A functional cooperativity between Aurora A kinase and LIM kinase1: implication in the mitotic process Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation.Signaling-dependent phosphorylation of mitotic centromere-associated kinesin regulates microtubule depolymerization and its centrosomal localization Aurora A kinase (AURKA) in normal and pathological cell division.Aurora A is involved in central spindle assembly through phosphorylation of Ser 19 in P150Glued Mitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2.MCAK and paclitaxel have differential effects on spindle microtubule organization and dynamics.Rho GTPase-independent regulation of mitotic progression by the RhoGEF Net1 Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins.Kinesin-13s in mitosis: Key players in the spatial and temporal organization of spindle microtubules.The molecular basis for kinesin functional specificity during mitosis.Intrinsic Disorder in the Kinesin Superfamily.Aurora kinases orchestrate mitosis; who are the players?The Elephant in the Room: The Role of Microtubules in Cancer.

P2860

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P2860

Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.

http://www.wikidata.org/entity/Q36739939

description

2008 nî lūn-bûn

@nan

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

2008年论文

@zh

2008年论文

@zh-cn

name

Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.

@ast

Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.

@en

type

label

Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.

@ast

Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.

@en

prefLabel

Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.

@ast

Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.

@en

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P356

MBC.E08-02-0198

P1433

Molecular Biology of the Cell

P1476

Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.

@en

P2093

Claire E Walczak

http://www.w3.org/2001/XMLSchema#string

Stephanie C Ems-McClung

http://www.w3.org/2001/XMLSchema#string

Xin Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation

TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly

Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A

Aurora B regulates MCAK at the mitotic centromere

Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1

Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide

Mitotic centromere-associated kinesin is important for anaphase chromosome segregation

Opposing motor activities are required for the organization of the mammalian mitotic spindle pole

MCAK associates with the tips of polymerizing microtubules

Dynein/dynactin regulate metaphase spindle length by targeting depolymerizing activities to spindle poles.

P304

2752-2765

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scholarly article

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10.1091/MBC.E08-02-0198

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7

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P478

19

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2008-04-23T00:00:00Z

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18434591

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P921

phosphorylation

P932

2441684

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