about
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitiveTwo TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth controlA pharmacological map of the PI3-K family defines a role for p110alpha in insulin signalingTOR signaling in growth and metabolismArsenic toxicity to Saccharomyces cerevisiae is a consequence of inhibition of the TORC1 kinase combined with a chronic stress responseTORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae.Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities.Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton.Molecular organization of target of rapamycin complex 2.Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization.Sch9 is a major target of TORC1 in Saccharomyces cerevisiae.The Vam6 GEF controls TORC1 by activating the EGO complex.Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis.Human ING1 proteins differentially regulate histone acetylationA neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeastCell growth control: little eukaryotes make big contributions.Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L.Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast.Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis.Mitochondrial genomic dysfunction causes dephosphorylation of Sch9 in the yeast Saccharomyces cerevisiae.Target of rapamycin (TOR) in nutrient signaling and growth controlTarget of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways.Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometryDual action antifungal small molecule modulates multidrug efflux and TOR signalingThe TOR signalling network from yeast to man.A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial DysfunctionFunctional interactions between sphingolipids and sterols in biological membranes regulating cell physiologyA pathway of targeted autophagy is induced by DNA damage in budding yeast.Roles for PI(3,5)P2 in nutrient sensing through TORC1.A brief history of TOR.Chemical biology approaches to membrane homeostasis and functionMutual antagonism of target of rapamycin and calcineurin signaling.TOR Complexes and the Maintenance of Cellular Homeostasis.TORC2 Structure and Function.Reciprocal Regulation of Target of Rapamycin Complex 1 and Potassium Accumulation.Caffeine extends yeast lifespan by targeting TORC1.Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling.Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.Pho23 is associated with the Rpd3 histone deacetylase and is required for its normal function in regulation of gene expression and silencing in Saccharomyces cerevisiae.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
ricercatore
@it
հետազոտող
@hy
name
Robbie Loewith
@ast
Robbie Loewith
@en
Robbie Loewith
@es
Robbie Loewith
@fr
Robbie Loewith
@nl
Robbie Loewith
@sl
type
label
Robbie Loewith
@ast
Robbie Loewith
@en
Robbie Loewith
@es
Robbie Loewith
@fr
Robbie Loewith
@nl
Robbie Loewith
@sl
prefLabel
Robbie Loewith
@ast
Robbie Loewith
@en
Robbie Loewith
@es
Robbie Loewith
@fr
Robbie Loewith
@nl
Robbie Loewith
@sl
P1053
S-6289-2016
P106
P1960
rhQIMFIAAAAJ
P21
P214
4204155044733372520002
P31
P3829
P496
0000-0002-2482-603X
P569
2000-01-01T00:00:00Z
P735
P7859
viaf-4204155044733372520002