A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling - Test2 - elhamkhani - TriplyDB

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

http://www.wikidata.org/entity/Q24599676

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2 Should individual PI3 kinase isoforms be targeted in cancer?Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer Akt and autophagy cooperate to promote survival of drug-resistant glioma The PI3K pathway as drug target in human cancer Rapamycin and mTOR kinase inhibitors PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration Deciphering the roles of phosphoinositide lipids in phagolysosome biogenesis Pharmacodynamic Biomarker Development for PI3K Pathway Therapeutics Other targeted drugs in melanoma DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer The PTEN tumor suppressor gene and its role in lymphoma pathogenesis The Role of the PI3K Pathway in the Regeneration of the Damaged Brain by Neural Stem Cells after Cerebral Infarction Photoreceptor cell death and rescue in retinal detachment and degenerations Phosphoinositides: tiny lipids with giant impact on cell regulation Spontaneous and electric field-controlled front-rear polarization of human keratinocytes Investigating the structure and dynamics of the PIK3CA wild-type and H1047R oncogenic mutant PI3Ks maintain the structural integrity of T-tubules in cardiac myocytes Interaction of ARF-1.1 and neuronal calcium sensor-1 in the control of the temperature-dependency of locomotion in Caenorhabditis elegans Multiple phosphatidylinositol 3-kinases regulate vaccinia virus morphogenesis Molecular determinants and dynamics of hepatitis C virus secretion Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11 Structural insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1)Structure-Based Design of an Organoruthenium Phosphatidyl-inositol-3-kinase Inhibitor Reveals a Switch Governing Lipid Kinase Potency and Selectivity Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism mTOR kinase structure, mechanism and regulation A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation Structures of PI4KIII complexes show simultaneous recruitment of Rab11 and its effectors Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin Crystal Structures of PI3Kα Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design Engineering of an isolated p110α subunit of PI3Kα permits crystallization and provides a platform for structure-based drug design Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ Discovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946)The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis.Recent development of ATP-competitive small molecule phosphatidylinostitol-3-kinase inhibitors as anticancer agents In vitro models of cancer stem cells and clinical applications Chemical strategies for development of ATR inhibitors

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P2860

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

http://www.wikidata.org/entity/Q24599676

description

2006 nî lūn-bûn

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2006 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2006 թվականի մայիսին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

A pharmacological map of the P ...... p110alpha in insulin signaling

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A pharmacological map of the P ...... p110alpha in insulin signaling

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A pharmacological map of the P ...... p110alpha in insulin signaling

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type

label

A pharmacological map of the P ...... p110alpha in insulin signaling

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A pharmacological map of the P ...... p110alpha in insulin signaling

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A pharmacological map of the P ...... p110alpha in insulin signaling

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A pharmacological map of the P ...... p110alpha in insulin signaling

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A pharmacological map of the P ...... p110alpha in insulin signaling

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A pharmacological map of the P ...... p110alpha in insulin signaling

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A pharmacological map of the P ...... p110alpha in insulin signaling

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