Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins - Test2 - elhamkhani - TriplyDB

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

http://www.wikidata.org/entity/Q30040391

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A journey in bioinspired supramolecular chemistry: from molecular tweezers to small molecules that target myotonic dystrophy Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal models Dimer formation enhances structural differences between amyloid β-protein (1-40) and (1-42): an explicit-solvent molecular dynamics study EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanisms Reducing synuclein accumulation improves neuronal survival after spinal cord injury Molecular Tweezers Targeting Transthyretin Amyloidosis Neurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos Amyloid β-Protein Assembly: The Effect of Molecular Tweezers CLR01 and CLR03 Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues.Designed Trpzip-3 β-Hairpin Inhibits Amyloid Formation in Two Different Amyloid Systems Molecular basis for preventing α-synuclein aggregation by a molecular tweezer.Acetylation: a new key to unlock tau's role in neurodegeneration Nanoscale Control of Amyloid Self-Assembly Using Protein Phase Transfer by Host-Guest Chemistry A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.Cross dimerization of amyloid-β and αsynuclein proteins in aqueous environment: a molecular dynamics simulations study.An overview of drugs currently under investigation for the treatment of transthyretin-related hereditary amyloidosis.Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01.Transthyretin cardiac amyloidosis: pathogenesis, treatments, and emerging role in heart failure with preserved ejection fraction.A brief overview of amyloids and Alzheimer's disease.Structure and mechanism of action of tau aggregation inhibitors.Isolation and characterization of antibody fragments selective for toxic oligomeric tau Safety and pharmacological characterization of the molecular tweezer CLR01 - a broad-spectrum inhibitor of amyloid proteins' toxicity.Binding cavities and druggability of intrinsically disordered proteins.Computational re-engineering of Amylin sequence with reduced amyloidogenic potential.A molecular tweezer antagonizes seminal amyloids and HIV infection.Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01 Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42.Toward Improved Force-Field Accuracy through Sensitivity Analysis of Host-Guest Binding Thermodynamics.Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers.An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease.Peptides Composed of Alternating L- and D-Amino Acids Inhibit Amyloidogenesis in Three Distinct Amyloid Systems Independent of Sequence.Amino acid substitutions [K16A] and [K28A] distinctly affect amyloid β-protein oligomerization.Islet amyloid: from fundamental biophysics to mechanisms of cytotoxicity.Integrating Native Mass Spectrometry and Top-Down MS for Defining Protein Interactions Important in Biology and Medicine Mass Spectrometry Analysis of Lysine Posttranslational Modifications of Tau Protein from Alzheimer's Disease Brain.Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid beta species in Alzheimer's disease Intrinsically disordered proteins and novel strategies for drug discovery.Clearance of extracellular misfolded proteins in systemic amyloidosis: experience with transthyretin.The role of molecular simulations in the development of inhibitors of amyloid β-peptide aggregation for the treatment of Alzheimer's disease

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Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

http://www.wikidata.org/entity/Q30040391

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2011 nî lūn-bûn

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2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Lysine-Specific Molecular Twee ...... d Toxicity of Amyloid Proteins

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Journal of the American Chemical Society

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Lysine-Specific Molecular Twee ...... d Toxicity of Amyloid Proteins

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Akila Shanmugam

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Aleksey Lomakin

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Chunyu Wang

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Dahabada H. J. Lopes

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Eric S. Pang

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Frank-Gerrit Klärner

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Gal Bitan

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George B. Benedek

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Joseph A. Loo

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Kirsten McDaniel

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Top-down mass spectrometry of supercharged native protein–ligand complexes

Converting the Highly Amyloidogenic Human Calcitonin into a Powerful Fibril Inhibitor by Three-dimensional Structure Homology with a Non-amyloidogenic Analogue

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

Protein misfolding, functional amyloid, and human disease

A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

The effect of a DeltaK280 mutation on the unfolded state of a microtubule-binding repeat in Tau

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

Examining the influence of ultraviolet C irradiation on recombinant human γD-crystallin.

C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity.

Structural classification of toxic amyloid oligomers

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16958-16969

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scholarly article

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1223276

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10.1021/JA206279B

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42

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133

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Michael Ehrmann

Annette Tennstaedt

Sharmistha Sinha

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2011-10-26T00:00:00Z

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51642462

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21916458

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3210512

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