Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins
about
A journey in bioinspired supramolecular chemistry: from molecular tweezers to small molecules that target myotonic dystrophyDisrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal modelsDimer formation enhances structural differences between amyloid β-protein (1-40) and (1-42): an explicit-solvent molecular dynamics studyEPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaquesModulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanismsReducing synuclein accumulation improves neuronal survival after spinal cord injuryMolecular Tweezers Targeting Transthyretin AmyloidosisNeurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish EmbryosAmyloid β-Protein Assembly: The Effect of Molecular Tweezers CLR01 and CLR03Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues.Designed Trpzip-3 β-Hairpin Inhibits Amyloid Formation in Two Different Amyloid SystemsMolecular basis for preventing α-synuclein aggregation by a molecular tweezer.Acetylation: a new key to unlock tau's role in neurodegenerationNanoscale Control of Amyloid Self-Assembly Using Protein Phase Transfer by Host-Guest ChemistryA novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.Cross dimerization of amyloid-β and αsynuclein proteins in aqueous environment: a molecular dynamics simulations study.An overview of drugs currently under investigation for the treatment of transthyretin-related hereditary amyloidosis.Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01.Transthyretin cardiac amyloidosis: pathogenesis, treatments, and emerging role in heart failure with preserved ejection fraction.A brief overview of amyloids and Alzheimer's disease.Structure and mechanism of action of tau aggregation inhibitors.Isolation and characterization of antibody fragments selective for toxic oligomeric tauSafety and pharmacological characterization of the molecular tweezer CLR01 - a broad-spectrum inhibitor of amyloid proteins' toxicity.Binding cavities and druggability of intrinsically disordered proteins.Computational re-engineering of Amylin sequence with reduced amyloidogenic potential.A molecular tweezer antagonizes seminal amyloids and HIV infection.Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42.Toward Improved Force-Field Accuracy through Sensitivity Analysis of Host-Guest Binding Thermodynamics.Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers.An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease.Peptides Composed of Alternating L- and D-Amino Acids Inhibit Amyloidogenesis in Three Distinct Amyloid Systems Independent of Sequence.Amino acid substitutions [K16A] and [K28A] distinctly affect amyloid β-protein oligomerization.Islet amyloid: from fundamental biophysics to mechanisms of cytotoxicity.Integrating Native Mass Spectrometry and Top-Down MS for Defining Protein Interactions Important in Biology and MedicineMass Spectrometry Analysis of Lysine Posttranslational Modifications of Tau Protein from Alzheimer's Disease Brain.Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid beta species in Alzheimer's diseaseIntrinsically disordered proteins and novel strategies for drug discovery.Clearance of extracellular misfolded proteins in systemic amyloidosis: experience with transthyretin.The role of molecular simulations in the development of inhibitors of amyloid β-peptide aggregation for the treatment of Alzheimer's disease
P2860
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P2860
Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Lysine-Specific Molecular Twee ...... d Toxicity of Amyloid Proteins
@ast
Lysine-Specific Molecular Twee ...... d Toxicity of Amyloid Proteins
@en
type
label
Lysine-Specific Molecular Twee ...... d Toxicity of Amyloid Proteins
@ast
Lysine-Specific Molecular Twee ...... d Toxicity of Amyloid Proteins
@en
prefLabel
Lysine-Specific Molecular Twee ...... d Toxicity of Amyloid Proteins
@ast
Lysine-Specific Molecular Twee ...... d Toxicity of Amyloid Proteins
@en
P2093
P2860
P50
P3181
P356
P1476
Lysine-Specific Molecular Twee ...... d Toxicity of Amyloid Proteins
@en
P2093
Akila Shanmugam
Aleksey Lomakin
Chunyu Wang
Dahabada H. J. Lopes
Eric S. Pang
Frank-Gerrit Klärner
George B. Benedek
Joseph A. Loo
Kirsten McDaniel
P2860
P304
16958-16969
P3181
P356
10.1021/JA206279B
P407
P577
2011-10-26T00:00:00Z