A chemical rescue screen identifies a Plasmodium falciparum apicoplast inhibitor targeting MEP isoprenoid precursor biosynthesis
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Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and BeyondMuddled mechanisms: recent progress towards antimalarial target identificationNew Insight into Isoprenoids Biosynthesis Process and Future Prospects for Drug Designing in PlasmodiumDetermination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studiesMetabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action.MinorityReport, software for generalized analysis of causal genetic variantsPlasmid-free CRISPR/Cas9 genome editing in Plasmodium falciparum confirms mutations conferring resistance to the dihydroisoquinolone clinical candidate SJ733.Plasmodium IspD (2-C-Methyl-D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target.Structure of a putative ClpS N-end rule adaptor protein from the malaria pathogen Plasmodium falciparum.Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways.Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspDCulture adaptation of malaria parasites selects for convergent loss-of-function mutants.Screening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery.The Candidate Antimalarial Drug MMV665909 Causes Oxygen-Dependent mRNA Mistranslation and Synergizes with Quinoline-Derived Antimalarials.Phenotypic Screens in Antimalarial Drug Discovery.Identification of Plasmodium falciparum specific translation inhibitors from the MMV Malaria Box using a high throughput in vitro translation screenThe apicoplast: now you see it, now you don't.Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens.Biological Studies and Target Engagement of the 2-C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1R,3S)-MMV008138 and Analogs.Validation of Putative Apicoplast-Targeting Drugs Using a Chemical Supplementation Assay in Cultured Human Malaria Parasites.Specific Inhibition of the Bifunctional Farnesyl/Geranylgeranyl Diphosphate Synthase in Malaria Parasites via a New Small-Molecule Binding Site.Targeted Phenotypic Screening in Plasmodium falciparum and Toxoplasma gondii Reveals Novel Modes of Action of Medicines for Malaria Venture Malaria Box Molecules.Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery.Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites
P2860
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P2860
A chemical rescue screen identifies a Plasmodium falciparum apicoplast inhibitor targeting MEP isoprenoid precursor biosynthesis
description
2015 nî lūn-bûn
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2015 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
A chemical rescue screen ident ...... prenoid precursor biosynthesis
@ast
A chemical rescue screen ident ...... prenoid precursor biosynthesis
@en
type
label
A chemical rescue screen ident ...... prenoid precursor biosynthesis
@ast
A chemical rescue screen ident ...... prenoid precursor biosynthesis
@en
prefLabel
A chemical rescue screen ident ...... prenoid precursor biosynthesis
@ast
A chemical rescue screen ident ...... prenoid precursor biosynthesis
@en
P2093
P2860
P921
P3181
P356
P1476
A chemical rescue screen ident ...... prenoid precursor biosynthesis
@en
P2093
Danny Ebert
Joseph L DeRisi
Katie Baska
Seok H Cho
Zachary Herrera
P2860
P304
P3181
P356
10.1128/AAC.03342-14
P407
P577
2015-01-01T00:00:00Z