Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation. - Test2 - elhamkhani - TriplyDB

Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation.

Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation.

http://www.wikidata.org/entity/Q30164872

about

The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1 Regulated association of protein kinase B/Akt with breast tumor kinase c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways CARMA1 is required for Akt-mediated NF-kappaB activation in T cells.Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex Csk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation PI3K-independent AKT activation in cancers: a treasure trove for novel therapeutics A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes The Cell Collective: toward an open and collaborative approach to systems biology.c-Jun regulates phosphoinositide-dependent kinase 1 transcription: implication for Akt and protein kinase C activities and melanoma tumorigenesis Combined SFK/mTOR inhibition prevents rapamycin-induced feedback activation of AKT and elicits efficient tumor regression.Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a ß-arrestin2/Src/Akt signaling complex in vivo Regulation of Akt signaling activation by ubiquitination.The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module.Integrin α3β1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt Classifying kinase conformations using a machine learning approach.Distinct interactions between c-Src and c-Met in mediating resistance to c-Src inhibition in head and neck cancer.Identification of functional domains in AKT responsible for distinct roles of AKT isoforms in pressure-stimulated cancer cell adhesion.Delta-catenin-induced dendritic morphogenesis. An essential role of p190RhoGEF interaction through Akt1-mediated phosphorylation.A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity Src inhibition blocks renal interstitial fibroblast activation and ameliorates renal fibrosis.JAK2, but not Src family kinases, is required for STAT, ERK, and Akt signaling in response to growth hormone in preadipocytes and hepatoma cells.Effects of dasatinib on EphA2 receptor tyrosine kinase activity and downstream signalling in pancreatic cancer.The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail.Arsenic alters vascular smooth muscle cell focal adhesion complexes leading to activation of FAK-src mediated pathways.Src tyrosine kinase signaling antagonizes nuclear localization of FOXO and inhibits its transcription factor activity.β-Arrestins: multifunctional signaling adaptors in type 2 diabetes.Aberrant regulation and function of Src family tyrosine kinases: their potential contributions to glutamate-induced neurotoxicity.Mammalian TOR signaling to the AGC kinases.Evolutionary Adaptations of Plant AGC Kinases: From Light Signaling to Cell Polarity Regulation KinView: a visual comparative sequence analysis tool for integrated kinome research.Akt/PKB: one kinase, many modifications.Inhibition of Src by microRNA-23b increases the cisplatin sensitivity of chondrosarcoma cells.Presence and utility of intrinsically disordered regions in kinases.Phosphatidylethanolamine-binding protein 4 is associated with breast cancer metastasis through Src-mediated Akt tyrosine phosphorylation.Palmitate contributes to insulin resistance through downregulation of the Src-mediated phosphorylation of Akt in C2C12 myotubes.The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU.

P2860

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P2860

Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation.

http://www.wikidata.org/entity/Q30164872

description

2003 nî lūn-bûn

@nan

2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2003年の論文

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2003年論文

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2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

Interaction between Src and a ...... s required for Akt activation.

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Interaction between Src and a ...... s required for Akt activation.

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type

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Interaction between Src and a ...... s required for Akt activation.

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Interaction between Src and a ...... s required for Akt activation.

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prefLabel

Interaction between Src and a ...... s required for Akt activation.

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Interaction between Src and a ...... s required for Akt activation.

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P1433

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P2860

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P1433

Journal of Biological Chemistry

P1476

Interaction between Src and a ...... s required for Akt activation.

@en

P2093

Tianyun Jiang

http://www.w3.org/2001/XMLSchema#string

Yun Qiu

http://www.w3.org/2001/XMLSchema#string

P2860

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation

The PI3K-PDK1 connection: more than just a road to PKB

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking

Regulation of Akt/PKB activation by tyrosine phosphorylation

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

Structural determinants for the biological activity of Vav proteins.

Mechanism of protein kinase B activation by insulin/insulin-like growth factor-1 revealed by specific inhibitors of phosphoinositide 3-kinase--significance for diabetes and cancer.

The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C.

P304

15789-15793

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scholarly article

P356

10.1074/JBC.M212525200

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P433

18

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P478

278

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2003-02-24T00:00:00Z

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P698

12600984

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