Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a ß-arrestin2/Src/Akt signaling complex in vivo
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Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model.Addressing the Complexity of Tourette's Syndrome through the Use of Animal Models.The role of serotonin 5-HT2A receptors in memory and cognitionSerotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorderRecent advances in the neuropsychopharmacology of serotonergic hallucinogensPsychedelicsSerotonergic regulation of excitability of principal cells of the dorsal cochlear nucleus.Characterization of the head-twitch response induced by hallucinogens in mice: detection of the behavior based on the dynamics of head movement.Regulating prefrontal cortex activation: an emerging role for the 5-HT₂A serotonin receptor in the modulation of emotion-based actions?Clozapine acts as an agonist at serotonin 2A receptors to counter MK-801-induced behaviors through a βarrestin2-independent activation of AktNeuronal ablation of p-Akt at Ser473 leads to altered 5-HT1A/2A receptor functionInteraction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes.Effects of the hallucinogen 2,5-dimethoxy-4-iodophenethylamine (2C-I) and superpotent N-benzyl derivatives on the head twitch response.Serotonin 5-HT₂ receptor activation prevents allergic asthma in a mouse modelReduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorderEmerging paradigms of β-arrestin-dependent seven transmembrane receptor signalingFunctional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance.Serotonergic and dopaminergic distinctions in the behavioral pharmacology of (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD).Noradrenergic antidepressant responses to desipramine in vivo are reciprocally regulated by arrestin3 and spinophilin.Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.Functional selectivity of kappa opioid receptor agonists in peripheral sensory neurons.Serotonin 2a Receptor and Serotonin 1a Receptor Interact Within the Medial Prefrontal Cortex During Recognition Memory in MiceSerine 363 is required for nociceptin/orphanin FQ opioid receptor (NOPR) desensitization, internalization, and arrestin signaling.Phospholipase C mediates (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-, but not lysergic acid diethylamide (LSD)-elicited head bobs in rabbit medial prefrontal cortexSerotonin receptor signaling and regulation via β-arrestins.A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicitySupport for 5-HT2C receptor functional selectivity in vivo utilizing structurally diverse, selective 5-HT2C receptor ligands and the 2,5-dimethoxy-4-iodoamphetamine elicited head-twitch response modelMetformin Enhances the Therapy Effects of Anti-IGF-1R mAb Figitumumab to NSCLC.Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at κ-opioid receptors in striatal neurons.Transduction of group I mGluR-mediated synaptic plasticity by β-arrestin2 signalling.Minireview: More than just a hammer: ligand "bias" and pharmaceutical discovery.Novel pathways in gonadotropin receptor signaling and biased agonism.Glycogen Synthase Kinase-3 is an Intermediate Modulator of Serotonin NeurotransmissionFunctional selectivity in GPCR heterocomplexes.Therapeutic mechanisms of classic hallucinogens in the treatment of addictions: from indirect evidence to testable hypotheses.Serotonin-glutamate and serotonin-dopamine reciprocal interactions as putative molecular targets for novel antipsychotic treatments: from receptor heterodimers to postsynaptic scaffolding and effector proteins.Functional selectivity of GPCR signaling in animals.Biased agonism: An emerging paradigm in GPCR drug discovery.Heat-shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK mitogen-activated protein kinase (MAPK) mechanism in mouse brain.Functional selectivity at G-protein coupled receptors: Advancing cannabinoid receptors as drug targets.
P2860
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P2860
Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a ß-arrestin2/Src/Akt signaling complex in vivo
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2010 nî lūn-bûn
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2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
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2010年論文
@zh-hant
2010年論文
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2010年論文
@zh-mo
2010年論文
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2010年论文
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name
Serotonin, but not N-methyltry ...... /Akt signaling complex in vivo
@ast
Serotonin, but not N-methyltry ...... /Akt signaling complex in vivo
@en
Serotonin, but not N-methyltry ...... /Akt signaling complex in vivo
@nl
type
label
Serotonin, but not N-methyltry ...... /Akt signaling complex in vivo
@ast
Serotonin, but not N-methyltry ...... /Akt signaling complex in vivo
@en
Serotonin, but not N-methyltry ...... /Akt signaling complex in vivo
@nl
prefLabel
Serotonin, but not N-methyltry ...... /Akt signaling complex in vivo
@ast
Serotonin, but not N-methyltry ...... /Akt signaling complex in vivo
@en
Serotonin, but not N-methyltry ...... /Akt signaling complex in vivo
@nl
P2860
P1476
Serotonin, but not N-methyltry ...... /Akt signaling complex in vivo
@en
P2093
Cullen L Schmid
P2860
P304
13513-13524
P356
10.1523/JNEUROSCI.1665-10.2010
P407
P50
P577
2010-10-01T00:00:00Z