Zonula occludens-1 is a scaffolding protein for signaling molecules. Galpha(12) directly binds to the Src homology 3 domain and regulates paracellular permeability in epithelial cells.
about
Interaction of the human somatostatin receptor 3 with the multiple PDZ domain protein MUPP1 enables somatostatin to control permeability of epithelial tight junctionsBlood-brain barrier integrity and glial support: mechanisms that can be targeted for novel therapeutic approaches in strokeEpithelial barrier assembly requires coordinated activity of multiple domains of the tight junction protein ZO-1Association between segments of zonula occludens proteins: live-cell FRET and mass spectrometric analysis.ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton.Zonula occludens-1 function in the assembly of tight junctions in Madin-Darby canine kidney epithelial cells.Galpha12 regulates epithelial cell junctions through Src tyrosine kinases.Polycystin-1 protein level determines activity of the Galpha12/JNK apoptosis pathway.Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1.The hinge region of the scaffolding protein of cell contacts, zonula occludens protein 1, regulates interacting with various signaling proteins.The active Zot domain (aa 288-293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding partners, and induces tight junction disassembly through proteinase activated receptor 2 activationOccludin S408 phosphorylation regulates tight junction protein interactions and barrier functionPolycystin-1 and Gα12 regulate the cleavage of E-cadherin in kidney epithelial cellsNeuronal connexin36 association with zonula occludens-1 protein (ZO-1) in mouse brain and interaction with the first PDZ domain of ZO-1.The tight junction: a multifunctional complex.Targeting blood-brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery.Gα12 activation in podocytes leads to cumulative changes in glomerular collagen expression, proteinuria and glomerulosclerosis.H2O2 activates G protein, α 12 to disrupt the junctional complex and enhance ischemia reperfusion injuryRho GTP exchange factor ARHGEF11 regulates the integrity of epithelial junctions by connecting ZO-1 and RhoA-myosin II signaling.Claudin-1 expression confers resistance to anoikis in colon cancer cells in a Src-dependent mannerG protein α12 (Gα12) is a negative regulator of kidney injury molecule-1-mediated efferocytosis.Proteins and mechanisms regulating gap-junction assembly, internalization, and degradation.Role of G12 proteins in oncogenesis and metastasisHeterotrimeric G proteins and apoptosis: intersecting signaling pathways leading to context dependent phenotypesParacellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertensionRho signaling and tight junction functions.The dual role of zonula occludens (ZO) proteins.New aspects of the molecular constituents of tissue barriers.Beyond cell-cell adhesion: Emerging roles of the tight junction scaffold ZO-2.Endothelial cell signaling and ventilator-induced lung injury: molecular mechanisms, genomic analyses, and therapeutic targets.Regulation of integrin expression by Gα12: An additional potential mechanism modulating cell attachment.Divergent roles of prokineticin receptors in the endothelial cells: angiogenesis and fenestration.G alpha 12 inhibits alpha2 beta1 integrin-mediated Madin-Darby canine kidney cell attachment and migration on collagen-I and blocks tubulogenesis.Galpha12 stimulates apoptosis in epithelial cells through JNK1-mediated Bcl-2 degradation and up-regulation of IkappaBalpha.Selective uncoupling of G alpha 12 from Rho-mediated signaling.Gα12 is required for renal cystogenesis induced by Pkd1 inactivation.Melatonin and Hippo Pathway: Is There Existing Cross-Talk?ARHGEF11, a regulator of junction-associated actomyosin in epithelial cells.Identification of new binding partners of the chemosensory signaling protein Gγ13 expressed in taste and olfactory sensory cells.IBD candidate genes and intestinal barrier regulation.
P2860
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P2860
Zonula occludens-1 is a scaffolding protein for signaling molecules. Galpha(12) directly binds to the Src homology 3 domain and regulates paracellular permeability in epithelial cells.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Zonula occludens-1 is a scaffo ...... meability in epithelial cells.
@ast
Zonula occludens-1 is a scaffo ...... meability in epithelial cells.
@en
type
label
Zonula occludens-1 is a scaffo ...... meability in epithelial cells.
@ast
Zonula occludens-1 is a scaffo ...... meability in epithelial cells.
@en
prefLabel
Zonula occludens-1 is a scaffo ...... meability in epithelial cells.
@ast
Zonula occludens-1 is a scaffo ...... meability in epithelial cells.
@en
P2093
P356
P1476
Zonula occludens-1 is a scaffo ...... meability in epithelial cells.
@en
P2093
Bradley M Denker
Catherine Schwesinger
Tobias N Meyer
P304
24855-24858
P356
10.1074/JBC.C200240200
P407
P577
2002-05-21T00:00:00Z