Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain.
about
A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization.Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancerNaturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitorsA unique set of SH3-SH3 interactions controls IB1 homodimerization.Activation of MTK1/MEKK4 by GADD45 through induced N-C dissociation and dimerization-mediated trans autophosphorylation of the MTK1 kinase domainMLK3 Signaling in Cancer InvasionAkt2 negatively regulates assembly of the POSH-MLK-JNK signaling complexRegulation of mixed-lineage kinase activation in JNK-dependent morphogenesis.Regulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions.Cdc42 induces activation loop phosphorylation and membrane targeting of mixed lineage kinase 3.Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours.Domain specificity of MAP3K family members, MLK and Tak1, for JNK signaling in DrosophilaDrosophila heat shock response requires the JNK pathway and phosphorylation of mixed lineage kinase at a conserved serine-proline motif.Mixed-lineage kinase control of JNK and p38 MAPK pathways.Inhibition of Cdc42-mediated activation of mixed lineage kinase 3 by the tumor suppressor protein merlin.Genetic analysis of slipper/mixed lineage kinase reveals requirements in multiple Jun-N-terminal kinase-dependent morphogenetic events during Drosophila development.PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulationDecrement of miR-199a-5p contributes to the tumorigenesis of bladder urothelial carcinoma by regulating MLK3/NF-κB pathwayMixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity?Mixed Lineage Kinase-c-Jun N-Terminal Kinase Axis: A Potential Therapeutic Target in Cancer.Cytokine-induced activation of mixed lineage kinase 3 requires TRAF2 and TRAF6.Involvement of mixed lineage kinase 3 in cancer.Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: a MLK-3-MKK7-dependent mechanism.Inhibition of mixed-lineage kinase (MLK) activity during G2-phase disrupts microtubule formation and mitotic progression in HeLa cells.Induced, selective proteolysis of MLK3 negatively regulates MLK3/JNK signalling.Dynamic positive feedback phosphorylation of mixed lineage kinase 3 by JNK reversibly regulates its distribution to Triton-soluble domains.Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling.K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK.Mutational analysis of stress-responsive peanut dual specificity protein kinase. Identification of tyrosine residues involved in regulation of protein kinase activity.Knock-down of POSH expression is neuroprotective through down-regulating activation of the MLK3-MKK4-JNK pathway following cerebral ischaemia in the rat hippocampal CA1 subfield.Perlecan Domain V Inhibits Amyloid-β Induced Activation of the α2β1 Integrin-Mediated Neurotoxic Signaling Cascade.Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3
P2860
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P2860
Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain.
description
2001 nî lūn-bûn
@nan
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain.
@ast
Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain.
@en
type
label
Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain.
@ast
Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain.
@en
prefLabel
Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain.
@ast
Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain.
@en
P2860
P356
P1476
Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain.
@en
P2093
P2860
P304
45598-45603
P356
10.1074/JBC.M107176200
P407
P577
2001-12-01T00:00:00Z