Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling. - Test2 - elhamkhani - TriplyDB

Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling.

Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling.

http://www.wikidata.org/entity/Q40582216

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MLK3 Signaling in Cancer Invasion MLK3 regulates fMLP-stimulated neutrophil motility.Cdc42 induces activation loop phosphorylation and membrane targeting of mixed lineage kinase 3.Domain specificity of MAP3K family members, MLK and Tak1, for JNK signaling in Drosophila Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's disease Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte.The E3 ligase CHIP mediates ubiquitination and degradation of mixed-lineage kinase 3 Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells.PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation Unravelling druggable signalling networks that control F508del-CFTR proteostasis MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF.HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth.Inhibition of mixed-lineage kinase (MLK) activity during G2-phase disrupts microtubule formation and mitotic progression in HeLa cells.Pharmacological inhibition of HSP90 activity negatively modulates myogenic differentiation and cell survival in C2C12 cells.Dynamic positive feedback phosphorylation of mixed lineage kinase 3 by JNK reversibly regulates its distribution to Triton-soluble domains.MLK3 regulates FRA-1 and MMPs to drive invasion and transendothelial migration in triple-negative breast cancer cells.An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client.Osmotic and heat stress-dependent regulation of MLK4β and MLK3 by the CHIP E3 ligase in ovarian cancer cells.Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3 Hsp90 Recognizes a Common Surface on Client Kinases

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P2860

Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling.

http://www.wikidata.org/entity/Q40582216

description

2004 nî lūn-bûn

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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2004年论文

@zh

2004年论文

@zh-cn

name

Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling.

@en

type

label

Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling.

@en

prefLabel

Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling.

@en

P1433

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P1433

Journal of Biological Chemistry

P1476

Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling.

@en

P2093

Hua Zhang

http://www.w3.org/2001/XMLSchema#string

Jack T Watson

http://www.w3.org/2001/XMLSchema#string

Kathleen A Gallo

http://www.w3.org/2001/XMLSchema#string

Nicholas Grammatikakis

http://www.w3.org/2001/XMLSchema#string

Sarah J Santos

http://www.w3.org/2001/XMLSchema#string

Susan E Conrad

http://www.w3.org/2001/XMLSchema#string

Wei Wu

http://www.w3.org/2001/XMLSchema#string

Yan Du

http://www.w3.org/2001/XMLSchema#string

P2860

Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation

MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription.

Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade

The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis

P304

19457-19463

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scholarly article

P356

10.1074/JBC.M311377200

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P433

19

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279

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2004-03-04T00:00:00Z

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15001580

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