The Shp-2 tyrosine phosphatase activates the Src tyrosine kinase by a non-enzymatic mechanism.
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Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell linesThe interaction of Src and RACK1 is enhanced by activation of protein kinase C and tyrosine phosphorylation of RACK1The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signalingThe mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradationRegulation of SRC family kinases in human cancersCannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowthRole of SHP-2 tyrosine phosphatase in the DNA damage-induced cell death response.Regulation of c-SRC activity and function by the adapter protein CASA novel role for ezrin in breast cancer angio/lymphangiogenesis.Tyrosine phosphatases such as SHP-2 act in a balance with Src-family kinases in stabilization of postsynaptic clusters of acetylcholine receptors.PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice.Role of SHPS-1 in the regulation of insulin-like growth factor I-stimulated Shc and mitogen-activated protein kinase activation in vascular smooth muscle cells.PZR coordinates Shp2 Noonan and LEOPARD syndrome signaling in zebrafish and mice.Selected glimpses into the activation and function of Src kinase.SHP2 mediates the localized activation of Fyn downstream of the α6β4 integrin to promote carcinoma invasion.Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathwayThe role of the protein tyrosine phosphatase SHP2 in cardiac development and disease.SHP-2 Mediates Cryptosporidium parvum Infectivity in Human Intestinal Epithelial Cells.Transcriptional signature induced by a metastasis-promoting c-Src mutant in a human breast cell line.Critical role of Src and SHP-2 in sst2 somatostatin receptor-mediated activation of SHP-1 and inhibition of cell proliferationPotential molecular mechanism for c-Src kinase-mediated regulation of intestinal cell migration.Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma.Molecular events associated with CD4-mediated Down-regulation of LFA-1-dependent adhesion.Pharmacology of Src family kinases and therapeutic implications of their modulators.Kindlin-2 phosphorylation by Src at Y193 enhances Src activity and is involved in Migfilin recruitment to the focal adhesions.Amplification of MPZL1/PZR gene in hepatocellular carcinoma.The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFRα and PDGFRα D842V.Loss of tyrosine phosphatase-dependent inhibition promotes activation of tyrosine kinase c-Src in detached pancreatic cells.The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition.A suggested role for mitochondria in Noonan syndrome.Shp2 is required for protein kinase C-dependent phosphorylation of serine 307 in insulin receptor substrate-1.Expression of a dominant negative SHP-2 in transgenic mice induces insulin resistance.The role of Src kinase in insulin-like growth factor-dependent mitogenic signaling in vascular smooth muscle cells.Global assessment of its network dynamics reveals that the kinase Plk1 inhibits the phosphatase PP6 to promote Aurora A activity.Increased insulin-stimulated Akt pSer473 and cytosolic SHP2 protein abundance in human skeletal muscle following acute exercise and short-term training
P2860
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P2860
The Shp-2 tyrosine phosphatase activates the Src tyrosine kinase by a non-enzymatic mechanism.
description
1999 nî lūn-bûn
@nan
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The Shp-2 tyrosine phosphatase ...... by a non-enzymatic mechanism.
@ast
The Shp-2 tyrosine phosphatase ...... by a non-enzymatic mechanism.
@en
type
label
The Shp-2 tyrosine phosphatase ...... by a non-enzymatic mechanism.
@ast
The Shp-2 tyrosine phosphatase ...... by a non-enzymatic mechanism.
@en
prefLabel
The Shp-2 tyrosine phosphatase ...... by a non-enzymatic mechanism.
@ast
The Shp-2 tyrosine phosphatase ...... by a non-enzymatic mechanism.
@en
P2093
P2860
P356
P1433
P1476
The Shp-2 tyrosine phosphatase ...... by a non-enzymatic mechanism.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1202513
P407
P577
1999-03-01T00:00:00Z
P5875
P6179
1010293211