Site-specific structural constraints on protein sequence evolutionary divergence: local packing density versus solvent exposure.
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Causes of evolutionary rate variation among protein sitesFunctional Sites Induce Long-Range Evolutionary Constraints in EnzymesDeterminants of the rate of protein sequence evolutionPredicting evolutionary site variability from structure in viral proteins: buriedness, packing, flexibility, and design.The conservation profile of a protein bears the imprint of the molecule that is evolutionarily coupled to the protein.(PS)2: protein structure prediction server version 3.0.Roles of solvent accessibility and gene expression in modeling protein sequence evolutionSequence Conservation, Radial Distance and Packing Density in Spherical Viral Capsids.The utility of protein structure as a predictor of site-wise dN/dS varies widely among HIV-1 proteins.Time dependence of evolutionary metrics during the 2009 pandemic influenza virus outbreak.Dissecting the roles of local packing density and longer-range effects in protein sequence evolutionBiophysical Models of Protein Evolution: Understanding the Patterns of Evolutionary Sequence Divergence.The Impact of Native State Switching on Protein Sequence Evolution.Computational prediction of the tolerance to amino-acid deletion in green-fluorescent protein.On the Relationship between Residue Structural Environment and Sequence Conservation in Proteins.A mechanistic stress model of protein evolution accounts for site-specific evolutionary rates and their relationship with packing density and flexibility.Local packing density is the main structural determinant of the rate of protein sequence evolution at site level.Biophysics of protein evolution and evolutionary protein biophysicsComputational survey of peptides derived from disulphide-bonded protein loops that may serve as mediators of protein-protein interactionsToo packed to change: side-chain packing and site-specific substitution rates in protein evolutionGeometric Constraints Dominate the Antigenic Evolution of Influenza H3N2 HemagglutininAlpha Helices Are More Robust to Mutations than Beta StrandsSynthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.Calculating site-specific evolutionary rates at the amino-acid or codon level yields similar rate estimates.Relationship between protein thermodynamic constraints and variation of evolutionary rates among sites.Intermediate divergence levels maximize the strength of structure-sequence correlations in enzymes and viral proteins.Measuring evolutionary rates of proteins in a structural context.Substitution rates predicted by stability-constrained models of protein evolution are not consistent with empirical data.Beyond Thermodynamic Constraints: Evolutionary Sampling Generates Realistic Protein Sequence Variation.Evolution of off-lattice model proteins under ligand binding constraints.In silico mutational studies of Hsp70 disclose sites with distinct functional attributes.Ensembles generated from crystal structures of single distant homologues solve challenging molecular-replacement cases in AMPLE.Influence of mutation bias and hydrophobicity on the substitution rates and sequence entropies of protein evolution
P2860
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P2860
Site-specific structural constraints on protein sequence evolutionary divergence: local packing density versus solvent exposure.
description
2013 nî lūn-bûn
@nan
2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Site-specific structural const ...... nsity versus solvent exposure.
@ast
Site-specific structural const ...... nsity versus solvent exposure.
@en
type
label
Site-specific structural const ...... nsity versus solvent exposure.
@ast
Site-specific structural const ...... nsity versus solvent exposure.
@en
prefLabel
Site-specific structural const ...... nsity versus solvent exposure.
@ast
Site-specific structural const ...... nsity versus solvent exposure.
@en
P2093
P2860
P50
P356
P1476
Site-specific structural const ...... nsity versus solvent exposure.
@en
P2093
Chien-Hua Shih
Jen-Wei Liu
Jenn-Kang Hwang
P2860
P304
P356
10.1093/MOLBEV/MST178
P577
2013-10-08T00:00:00Z