Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research.
about
TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike proteinPrinciples of Virus Uncoating: Cues and the Snooker BallCoronaviruses and the human airway: a universal system for virus-host interaction studiesAbelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion.Ebola virus and severe acute respiratory syndrome coronavirus display late cell entry kinetics: evidence that transport to NPC1+ endolysosomes is a rate-defining stepInhibition of proprotein convertases abrogates processing of the middle eastern respiratory syndrome coronavirus spike protein in infected cells but does not reduce viral infectivity.DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry.Structure, Function, and Evolution of Coronavirus Spike Proteins.Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus.Protease inhibitors targeting coronavirus and filovirus entryHost cell proteases: Critical determinants of coronavirus tropism and pathogenesisTwo Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome CoronavirusDifferent residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2.Cell-based antiviral screening against coronaviruses: developing virus-specific and broad-spectrum inhibitorsReceptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection.TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 influenza A virus in mice.Cell Entry of Porcine Epidemic Diarrhea Coronavirus Is Activated by Lysosomal Proteases.Calves are susceptible to infection with the newly emerged porcine deltacoronavirus, but not with the swine enteric alphacoronavirus, porcine epidemic diarrhea virus.Type II transmembrane serine proteases as potential target for anti-influenza drug discovery.Losartan and enalapril decrease viral absorption and interleukin 1 beta production by macrophages in an experimental dengue virus infection.Proteolytic activation of the porcine epidemic diarrhea coronavirus spike fusion protein by trypsin in cell culture.Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome: Current Therapeutic Options and Potential Targets for Novel Therapies.Host resilience to emerging coronaviruses
P2860
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P2860
Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research.
description
2013 nî lūn-bûn
@nan
2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Proteolytic activation of the ...... ng edge of antiviral research.
@ast
Proteolytic activation of the ...... ng edge of antiviral research.
@en
type
label
Proteolytic activation of the ...... ng edge of antiviral research.
@ast
Proteolytic activation of the ...... ng edge of antiviral research.
@en
prefLabel
Proteolytic activation of the ...... ng edge of antiviral research.
@ast
Proteolytic activation of the ...... ng edge of antiviral research.
@en
P2093
P2860
P921
P1433
P1476
Proteolytic activation of the ...... ng edge of antiviral research.
@en
P2093
Adeline Heurich
Graham Simmons
Stefanie Gierer
P2860
P304
P356
10.1016/J.ANTIVIRAL.2013.09.028
P577
2013-10-08T00:00:00Z