A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry
about
TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike proteinIdentification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assayMechanisms of coronavirus cell entry mediated by the viral spike proteinInfluenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tractsProteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research.Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice.DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry.Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza.Exposure to ozone modulates human airway protease/antiprotease balance contributing to increased influenza A infectionThe host protease TMPRSS2 plays a major role in in vivo replication of emerging H7N9 and seasonal influenza viruses.TMPRSS2 and MSPL Facilitate Trypsin-Independent Porcine Epidemic Diarrhea Virus Replication in Vero Cells.Structure, Function, and Evolution of Coronavirus Spike Proteins.Binding of the 5'-untranslated region of coronavirus RNA to zinc finger CCHC-type and RNA-binding motif 1 enhances viral replication and transcriptionCathepsin B & L are not required for ebola virus replicationNovel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanismsEvidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response.Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells.Role of proteases in the release of porcine epidemic diarrhea virus from infected cells.Coronavirus cell entry occurs through the endo-/lysosomal pathway in a proteolysis-dependent manner.Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like proteaseSARS-CoV and emergent coronaviruses: viral determinants of interspecies transmission.Impact of host proteases on reovirus infection in the respiratory tract.Host cell proteases: Critical determinants of coronavirus tropism and pathogenesisReady, set, fuse! The coronavirus spike protein and acquisition of fusion competenceSimultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry.Cleavage activation of the human-adapted influenza virus subtypes by matriptase reveals both subtype and strain specificities.Different residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2.Development of novel entry inhibitors targeting emerging viruses.The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies.Cleavage activation of human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12Differentiated phenotypes of primary murine alveolar epithelial cells and their susceptibility to infection by respiratory viruses.TMPRSS2 is an activating protease for respiratory parainfluenza viruses.Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2.Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropismClinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry.Cell-based antiviral screening against coronaviruses: developing virus-specific and broad-spectrum inhibitorsReceptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection.Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium.Membrane ectopeptidases targeted by human coronaviruses.TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells.
P2860
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P2860
A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
A transmembrane serine proteas ...... ptor and activates virus entry
@ast
A transmembrane serine proteas ...... ptor and activates virus entry
@en
A transmembrane serine proteas ...... ptor and activates virus entry
@en-gb
A transmembrane serine proteas ...... ptor and activates virus entry
@nl
type
label
A transmembrane serine proteas ...... ptor and activates virus entry
@ast
A transmembrane serine proteas ...... ptor and activates virus entry
@en
A transmembrane serine proteas ...... ptor and activates virus entry
@en-gb
A transmembrane serine proteas ...... ptor and activates virus entry
@nl
prefLabel
A transmembrane serine proteas ...... ptor and activates virus entry
@ast
A transmembrane serine proteas ...... ptor and activates virus entry
@en
A transmembrane serine proteas ...... ptor and activates virus entry
@en-gb
A transmembrane serine proteas ...... ptor and activates virus entry
@nl
P2093
P2860
P921
P356
P1433
P1476
A transmembrane serine proteas ...... ptor and activates virus entry
@en
P2093
Ana Shulla
Gitanjali Subramanya
Jincun Zhao
Tom Gallagher
P2860
P304
P356
10.1128/JVI.02062-10
P407
P577
2010-11-10T00:00:00Z