Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein. - Test2 - elhamkhani - TriplyDB

Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein.

Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein.

http://www.wikidata.org/entity/Q30434808

about

Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1 Identification and characterization of mitochondrial targeting sequence of human apurinic/apyrimidinic endonuclease 1 The association of APE1 -656T > G and 1349 T > G polymorphisms and cancer risk: a meta-analysis based on 37 case-control studies Structure of human apurinic/apyrimidinic endonuclease 1 with the essential Mg2+cofactor Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling Redox homeostasis: the linchpin in stem cell self-renewal and differentiation APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction Association of DNA Repair Gene APE1 Asp148Glu Polymorphism with Breast Cancer Risk.Mechanism of hypoxia-inducible factor 1 alpha-mediated Mcl1 regulation in Helicobacter pylori-infected human gastric epithelium.Regulation of signal transducer and activator of transcription 3 enhanceosome formation by apurinic/apyrimidinic endonuclease 1 in hepatic acute phase response.Chemical shift assignments for human apurinic/apyrimidinic endonuclease 1.Redox regulation of DNA repair: implications for human health and cancer therapeutic development.Diametrically opposed effects of hypoxia and oxidative stress on two viral transactivators Suppression of choroidal neovascularization through inhibition of APE1/Ref-1 redox activity.Involvement of oxidatively damaged DNA and repair in cancer development and aging.Redox Factor-1 Inhibits Cyclooxygenase-2 Expression via Inhibiting of p38 MAPK in the A549 Cells.APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1.Small molecule inhibitors of DNA repair nuclease activities of APE1.Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors.Posttranslational modification of mammalian AP endonuclease (APE1).Distinct roles of Ape1 protein, an enzyme involved in DNA repair, in high or low linear energy transfer ionizing radiation-induced cell killing.Redox regulation of apurinic/apyrimidinic endonuclease 1 activity in Long-Evans Cinnamon rats during spontaneous hepatitis Functional analysis of tanshinone IIA that blocks the redox function of human apurinic/apyrimidinic endonuclease 1/redox factor-1.DNA damage and base excision repair in mitochondria and their role in aging.Serum APE1 autoantibodies: a novel potential tumor marker and predictor of chemotherapeutic efficacy in non-small cell lung cancer Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway.Redox factor-1 activates endothelial SIRTUIN1 through reduction of conserved cysteine sulfhydryls in its deacetylase domain.Dual regulatory roles of human AP-endonuclease (APE1/Ref-1) in CDKN1A/p21 expression A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta.Identification and quantification of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) in human cells by liquid chromatography/isotope-dilution tandem mass spectrometry.Specific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell lines Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) redox function negatively regulates NRF2.Inhibition of APE1/Ref-1 redox activity rescues human retinal pigment epithelial cells from oxidative stress and reduces choroidal neovascularization.New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins.Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability All stressed out without ATM kinase

P2860

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P2860

Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein.

http://www.wikidata.org/entity/Q30434808

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2009 nî lūn-bûn

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2009 թուականի Մարտին հրատարակուած գիտական յօդուած

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2009 թվականի մարտին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Transcriptional regulatory fun ...... ntial multifunctional protein.

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Transcriptional regulatory fun ...... ntial multifunctional protein.

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Antioxidants & Redox Signaling

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Transcriptional regulatory fun ...... ntial multifunctional protein.

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Anil K Mantha

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Kishor K Bhakat

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Sankar Mitra

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P2860

Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation

Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter

Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1).

Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals

Identification of redox/repair protein Ref-1 as a potent activator of p53

The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium

A redox factor protein, ref1, is involved in negative gene regulation by extracellular calcium

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme

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621-638

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10.1089/ARS.2008.2198

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3

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11

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18715144

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2933571

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