Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability
about
The N-end rule pathwayDynamic Regulation of APE1/Ref-1 as a Therapeutic Target ProteinRepair of oxidative DNA damage and cancer: recent progress in DNA base excision repairBase Excision Repair, a Pathway Regulated by Posttranslational ModificationsThe E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammalsp53 coordinates base excision repair to prevent genomic instabilityNucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cellsNucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins.Base excision repair: a critical player in many gamesUbr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila.Pri sORF peptides induce selective proteasome-mediated protein processing.Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor propertiesBase excision repair: contribution to tumorigenesis and target in anticancer treatment paradigmsUbr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination.S-glutathionylation of cysteine 99 in the APE1 protein impairs abasic endonuclease activity.Cardiac Nav 1.5 is modulated by ubiquitin protein ligase E3 component n-recognin UBR3 and 6.Monoclonal antibodies against pools of mono- and polyacetylated peptides selectively recognize acetylated lysines within the context of the original antigenHuman apurinic/apyrimidinic endonuclease 1.Cellular accumulation of Cys326-OGG1 protein complexes under conditions of oxidative stress.Protein Quality Control by Molecular Chaperones in Neurodegeneration.Monitoring regulation of DNA repair activities of cultured cells in-gel using the comet assay.TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy.SILAC-Based Quantitative Proteomic Analysis Unveils Arsenite-Induced Perturbation of Multiple Pathways in Human Skin Fibroblast Cells.Frequently mutated genes/pathways and genomic instability as prevention targets in liver cancer.Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) in the modulation of its interaction with nucleic acids and NPM1 (nucleophosmin).Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin.UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis.
P2860
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P2860
Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability
description
2011 nî lūn-bûn
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2011年の論文
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2011年論文
@zh-hk
2011年論文
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name
Ubiquitin ligase UBR3 regulate ...... required for genome stability
@ast
Ubiquitin ligase UBR3 regulate ...... required for genome stability
@en
type
label
Ubiquitin ligase UBR3 regulate ...... required for genome stability
@ast
Ubiquitin ligase UBR3 regulate ...... required for genome stability
@en
prefLabel
Ubiquitin ligase UBR3 regulate ...... required for genome stability
@ast
Ubiquitin ligase UBR3 regulate ...... required for genome stability
@en
P2093
P2860
P50
P356
P1476
Ubiquitin ligase UBR3 regulate ...... required for genome stability
@en
P2093
Cornelia Meisenberg
Grigory L Dianov
Irina I Dianova
Takafumi Tasaki
Yong Tae Kwon
P2860
P304
P356
10.1093/NAR/GKR744
P407
P50
P577
2011-09-20T00:00:00Z