Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function - Test2 - elhamkhani - TriplyDB

Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function

Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function

http://www.wikidata.org/entity/Q30468589

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Early development of the vertebrate inner ear Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection.Swept-sine noise-induced damage as a hearing loss model for preclinical assays Application of insulin-like growth factor-1 in the treatment of inner ear disorders Three deaf mice: mouse models for TECTA-based human hereditary deafness reveal domain-specific structural phenotypes in the tectorial membrane The miR-183/Taok1 target pair is implicated in cochlear responses to acoustic trauma.Early otic development depends on autophagy for apoptotic cell clearance and neural differentiation.C-Raf deficiency leads to hearing loss and increased noise susceptibility.Treatment with N- and C-terminal peptides of parathyroid hormone-related protein partly compensate the skeletal abnormalities in IGF-I deficient mice.Long-Term Dietary Folate Deficiency Accelerates Progressive Hearing Loss on CBA/Ca Mice.Autophagy resolves early retinal inflammation in Igf1-deficient mice The Role of MicroRNAs in Environmental Risk Factors, Noise-Induced Hearing Loss, and Mental Stress.Expression of insulin signalling components in the sensory epithelium of the human saccule.Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in Age-Related Hearing Loss.The Role of Insulin-Like Growth Factor 1 in the Progression of Age-Related Hearing Loss.Zucker diabetic fatty rats, a model for type 2 diabetes, develop an inner ear dysfunction that can be attenuated by losartan treatment.Whole exome sequencing in adult-onset hearing loss reveals a high load of predicted pathogenic variants in known deafness-associated genes and identifies new candidate genes

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P2860

Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function

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2012 nî lūn-bûn

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2012年の論文

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MOLMED.2011.00328

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Molecular Medicine

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Insulin receptor substrate 2 ( ...... se 1B (PTP1B) loss of function

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Angela M Valverde

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Carlos Avendaño

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Deborah J Burks

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Guadalupe Camarero

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Lourdes Rodríguez De La Rosa

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Silvia Murillo-Cuesta

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P2860

Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in l6 myocytes and Fao hepatoma cells

Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts

Disruption of IRS-2 causes type 2 diabetes in mice

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation

Critical nodes in signalling pathways: insights into insulin action

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development.

Interactions of hearing loss and diabetes mellitus in the middle age CBA/CaJ mouse model of presbycusis.

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