Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos
about
α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1Architectural niche organization by LHX2 is linked to hair follicle stem cell functionWdr1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity.A role for the primary cilium in Notch signaling and epidermal differentiation during skin developmentGoverning epidermal homeostasis by coupling cell-cell adhesion to integrin and growth factor signaling, proliferation, and apoptosisMicro-ultrasound for preclinical imaging.Gene therapy for cardiovascular disease mediated by ultrasound and microbubbles.WNT-SHH Antagonism Specifies and Expands Stem Cells prior to Niche Formation.A Presenilin-2-ARF4 trafficking axis modulates Notch signaling during epidermal differentiationCoupling organelle inheritance with mitosis to balance growth and differentiationLaser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis.Accelerating cancer modeling with RNAi and nongermline genetically engineered mouse models.RNAi screening: new approaches, understandings, and organisms.Par3-mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN.RNAi-mediated gene function analysis in skin.Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation.SOX2 is a cancer-specific regulator of tumour initiating potential in cutaneous squamous cell carcinoma.Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice.miR-125b can enhance skin tumor initiation and promote malignant progression by repressing differentiation and prolonging cell survivalTranslation from unconventional 5' start sites drives tumour initiation.Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skinAsymmetric cell divisions promote Notch-dependent epidermal differentiation.Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesisStrand-specific in vivo screen of cancer-associated miRNAs unveils a role for miR-21(∗) in SCC progression.TGF-β promotes heterogeneity and drug resistance in squamous cell carcinomaParacrine TGF-β signaling counterbalances BMP-mediated repression in hair follicle stem cell activation.Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development.Life in the fast lane: mammalian disease models in the genomics era.Developmental mechanisms of stripe patterns in rodentsDirect reprogramming of fibroblasts into embryonic Sertoli-like cells by defined factorsEpidermal development, growth control, and homeostasis in the face of centrosome amplificationETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomasResponses of hair follicle-associated structures to loss of planar cell polarity signalingAn RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration.In vivo RNAi screens: concepts and applications.NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared nicheGenetic reconstitution of tumorigenesis in primary intestinal cellsRNAi screens in mice identify physiological regulators of oncogenic growthHair follicles' transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog.Silencing vimentin expression decreases pulmonary metastases in a pre-diabetic mouse model of mammary tumor progression.
P2860
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P2860
Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Rapid functional dissection of ...... tion and RNAi in mouse embryos
@ast
Rapid functional dissection of ...... tion and RNAi in mouse embryos
@en
type
label
Rapid functional dissection of ...... tion and RNAi in mouse embryos
@ast
Rapid functional dissection of ...... tion and RNAi in mouse embryos
@en
prefLabel
Rapid functional dissection of ...... tion and RNAi in mouse embryos
@ast
Rapid functional dissection of ...... tion and RNAi in mouse embryos
@en
P2860
P50
P356
P1433
P1476
Rapid functional dissection of ...... tion and RNAi in mouse embryos
@en
P2093
Geulah Livshits
P2860
P2888
P304
P356
10.1038/NM.2167
P407
P577
2010-06-06T00:00:00Z