A motor neuron disease-associated mutation in p150Glued perturbs dynactin function and induces protein aggregation.
about
pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular traffickingMissense mutations in the copper transporter gene ATP7A cause X-linked distal hereditary motor neuropathyMicrotubule plus-end tracking proteins in neuronal developmentAxonal transport disruption in peripheral nerve disease: From Jack's discoveries as a resident to recent contributionsdnc-1/dynactin 1 knockdown disrupts transport of autophagosomes and induces motor neuron degenerationThree-Dimensional Structure of CAP-Gly Domain of Mammalian Dynactin Determined by Magic Angle Spinning NMR Spectroscopy: Conformational Plasticity and Interactions with End-Binding Protein EB1Dynein and dynactin leverage their bivalent character to form a high-affinity interactionA Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During DiseaseTubulin-binding cofactor B is a direct interaction partner of the dynactin subunit p150(Glued)Regulators of the cytoplasmic dynein motorAggresome formation and neurodegenerative diseases: therapeutic implicationsArp11 affects dynein-dynactin interaction and is essential for dynein function in Aspergillus nidulans.ATP7A-related copper transport diseases-emerging concepts and future trendsExploring new pathways of neurodegeneration in ALS: the role of mitochondria quality controlγ-Tubulin Ring Complexes and EB1 play antagonistic roles in microtubule dynamics and spindle positioningMechanical dynamics in live cells and fluorescence-based force/tension sensorsRegulation of dynactin through the differential expression of p150Glued isoforms.Neurodegeneration mutations in dynactin impair dynein-dependent nuclear migration.Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes.Relay of retrograde synaptogenic signals through axonal transport of BMP receptors.The genetics of axonal transport and axonal transport disordersMotor neuron synapse and axon defects in a C. elegans alpha-tubulin mutant.Elucidating the genetics and pathology of Perry syndrome.DCTN1 mutations in Perry syndrome.Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?Novel dynein DYNC1H1 neck and motor domain mutations link distal spinal muscular atrophy and abnormal cortical developmentRetrograde axonal transport: pathways to cell death?Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43.Disease-associated mutations in the p150(Glued) subunit destabilize the CAP-gly domain.Dynactin is required for transport initiation from the distal axonGenetic rodent models of amyotrophic lateral sclerosisMotor neuron trophic factors: therapeutic use in ALS?P150glued-associated disorders are caused by activation of intrinsic apoptotic pathwayIn vivo roles of the basic domain of dynactin p150 in microtubule plus-end tracking and dynein functionDynactin functions as both a dynamic tether and brake during dynein-driven motility.Huntingtin facilitates dynein/dynactin-mediated vesicle transport.Altered intracellular localization and valosin-containing protein (p97 VCP) interaction underlie ATP7A-related distal motor neuropathyThe nuclear factor kappaB-activator gene PLEKHG5 is mutated in a form of autosomal recessive lower motor neuron disease with childhood onset.The p150(Glued) CAP-Gly domain regulates initiation of retrograde transport at synaptic termini.Microtubule binding by dynactin is required for microtubule organization but not cargo transport.
P2860
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P2860
A motor neuron disease-associated mutation in p150Glued perturbs dynactin function and induces protein aggregation.
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
A motor neuron disease-associa ...... d induces protein aggregation.
@ast
A motor neuron disease-associa ...... d induces protein aggregation.
@en
type
label
A motor neuron disease-associa ...... d induces protein aggregation.
@ast
A motor neuron disease-associa ...... d induces protein aggregation.
@en
prefLabel
A motor neuron disease-associa ...... d induces protein aggregation.
@ast
A motor neuron disease-associa ...... d induces protein aggregation.
@en
P2093
P2860
P356
P1476
A motor neuron disease-associa ...... d induces protein aggregation.
@en
P2093
Bernadette H LaMonte
Charlotte J Sumner
Erika L F Holzbaur
George G Harmison
Jennifer R Levy
Juliane P Caviston
Karen E Wallace
Kenneth H Fischbeck
Mariko K Tokito
P2860
P304
P356
10.1083/JCB.200511068
P407
P50
P577
2006-02-01T00:00:00Z