Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge. - Test2 - elhamkhani - TriplyDB

Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge.

Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge.

http://www.wikidata.org/entity/Q30490189

about

A novel GRK2/HDAC6 interaction modulates cell spreading and motility The dynamics of spatio-temporal Rho GTPase signaling: formation of signaling patterns Phosphorylation-mediated regulation of GEFs for RhoA The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration Targeting and transport: how microtubules control focal adhesion dynamics The exocyst at the interface between cytoskeleton and membranes in eukaryotic cells Rgnef (p190RhoGEF) knockout inhibits RhoA activity, focal adhesion establishment, and cell motility downstream of integrins Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion.The PI3K/Akt signaling pathway exerts effects on the implantation of mouse embryos by regulating the expression of RhoA Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1 Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration.The RhoA activator GEF-H1/Lfc is a transforming growth factor-beta target gene and effector that regulates alpha-smooth muscle actin expression and cell migration Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53 The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins.RhoB regulates cell migration through altered focal adhesion dynamics.Vincristine enhances amoeboid-like motility via GEF-H1/RhoA/ROCK/Myosin light chain signaling in MKN45 cells Central role of the exchange factor GEF-H1 in TNF-α-induced sequential activation of Rac, ADAM17/TACE, and RhoA in tubular epithelial cells.Localized RhoA GTPase activity regulates dynamics of endothelial monolayer integrity.GEF-H1 functions in apical constriction and cell intercalations and is essential for vertebrate neural tube closure.Poldip2 controls vascular smooth muscle cell migration by regulating focal adhesion turnover and force polarization.MYPT1 regulates contractility and microtubule acetylation to modulate integrin adhesions and matrix assembly TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion.RalB regulates contractility-driven cancer dissemination upon TGFβ stimulation via the RhoGEF GEF-H1 Homozygous ARHGEF2 mutation causes intellectual disability and midbrain-hindbrain malformation.Heparanase-induced GEF-H1 signaling regulates the cytoskeletal dynamics of brain metastatic breast cancer cells.p53 dependent centrosome clustering prevents multipolar mitosis in tetraploid cells Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4.Microtubule-dependent modulation of adhesion complex composition.Tiam1-Rac1 Axis Promotes Activation of p38 MAP Kinase in the Development of Diabetic Retinopathy: Evidence for a Requisite Role for Protein Palmitoylation Everolimus Stabilizes Podocyte Microtubules via Enhancing TUBB2B and DCDC2 Expression.Microtubules regulate GEF-H1 in response to extracellular matrix stiffness.Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization.Jun N-terminal kinase maintains tissue integrity during cell rearrangement in the gut.PDZ-RhoGEF is essential for CXCR4-driven breast tumor cell motility through spatial regulation of RhoA.PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front Post-polymerization crosstalk between the actin cytoskeleton and microtubule network.GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation.Extracellular signal-regulated kinase regulates RhoA activation and tumor cell plasticity by inhibiting guanine exchange factor H1 activity.A novel role for p115RhoGEF in regulation of epithelial plasticity.

P2860

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P2860

Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge.

http://www.wikidata.org/entity/Q30490189

description

2009 nî lūn-bûn

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2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հուլիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年学术文章

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2009年学术文章

@zh-cn

2009年学术文章

@zh-hans

2009年学术文章

@zh-my

2009年学术文章

@zh-sg

2009年學術文章

@yue

name

Guanine nucleotide exchange fa ...... n of RhoA at the leading edge.

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Guanine nucleotide exchange fa ...... n of RhoA at the leading edge.

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type

label

Guanine nucleotide exchange fa ...... n of RhoA at the leading edge.

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Guanine nucleotide exchange fa ...... n of RhoA at the leading edge.

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prefLabel

Guanine nucleotide exchange fa ...... n of RhoA at the leading edge.

@ast

Guanine nucleotide exchange fa ...... n of RhoA at the leading edge.

@en

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P356

MBC.E09-01-0041

P1433

Molecular Biology of the Cell

P1476

Guanine nucleotide exchange fa ...... n of RhoA at the leading edge.

@en

P2093

Gary M Bokoch

http://www.w3.org/2001/XMLSchema#string

Jörg Birkenfeld

http://www.w3.org/2001/XMLSchema#string

Perihan Nalbant

http://www.w3.org/2001/XMLSchema#string

Yuan-Chen Chang

http://www.w3.org/2001/XMLSchema#string

Zee-Fen Chang

http://www.w3.org/2001/XMLSchema#string

P2860

Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases

Localized Rac activation dynamics visualized in living cells

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

Activation of endogenous Cdc42 visualized in living cells

p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src

Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism

Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility

Stress fibers are generated by two distinct actin assembly mechanisms in motile cells

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4070-4082

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scholarly article

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10.1091/MBC.E09-01-0041

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18

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20

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2009-07-22T00:00:00Z

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19625450

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2743625

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